Frucard 20 mg+50 mg (Tablet)

Indications

• Essential hypertension
• Chronic congestive heart failure
• Hepatic cirrhosis
• Swelling due to excess fluid retention
• Hyperaldosteronism
• Resistant edema associated with secondary hyperaldosteronism

Pharmacology

• Complementary mechanisms and sites of action
• Additive or synergistic diuretic
• Inhibition of Na+/K+/2Cl- co-transporter
• Blockage of reabsorption of sodium, potassium, and chloride ions
• Induced potassium loss
• Inhibition of reabsorption of sodium in exchange for potassium
• Antagonizing the action of aldosterone

Dosage & Administration

• Dosage range of Furosemide 20 and spironolactone 50 mg
• Dosage range of Furosemide 40 and spironolactone 50 mg
• Not suitable for use in children
• Slower excretion in the elderly

Interaction

• Increased risk of hyperkalemia with ACE inhibitors or potassium salts
• Elevated levels of cardiac glycosides such as digoxin in the blood
• Potential digitalis toxicity
• Possible hypokalemia when used with corticosteroids
• Reduction of blood pressure lowering and diuretic effects when used with indomethacin and other NSAIDs
• Increased ototoxicity of aminoglycoside antibiotics in combination with Furosemide
• Reduced natriuretic and anti-hypertensive effect in simultaneous administration with sucralfate

Contraindications

• Anuria
• Acute renal insufficiency
• Severe impairment of renal function
• Hyperkalaemia
• Addison's disease
• Hypersensitivity to Spironolactone, Furosemide, or sulphonamides

Side Effects

• Headache
• Drowsiness
• Gastrointestinal distress
• Cramp
• Diarrhoea
• Ataxia
• Mental confusion
• Skin rashes
• Gynaecomastia
• Breast enlargement
• Hirsutism
• Deepening of the voice
• Menstrual irregularities
• Impotence
• Transient increase in blood-urea-nitrogen concentrations
• Mild acidosis
• Hyponatremia
• Excessive diuresis leading to dehydration
• Reduction in blood volume with circulatory collapse
• Serious depletion of potassium and magnesium leading to cardiac arrhythmias

Pregnancy & Lactation

• Crossing the placental barrier
• Animal teratology studies indicating possible fetal abnormalities
• Requirement for appropriate contraceptive measures in women of childbearing age
• Detection of metabolites in breast milk
• Discontinuation of breast-feeding if treatment is essential

Precautions & Warnings

• Caution in patients liable to electrolyte deficiency
• Use with caution in diabetes
• Enlarged prostate
• Hypotension
• Hypovolemia

Therapeutic Class

• Potassium-sparing diuretics
• Aldosterone antagonists

Storage Conditions

• Temperature below 30°C
• Protection from light and moisture
• Keep out of the reach of children

Related Brands

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