Inpen 1 gm/vial (IV Injection or Infusion)

1 gm vial: ৳ 1,300.00

Medicine Details

Category Details
Generic Meropenem trihydrate
Company Navana pharmaceuticals ltd
Also available as
Inpen 500 mg injection

Indications

  • Treatment of pneumonia and nosocomial pneumonia
  • Treatment of urinary tract infections
  • Treatment of intra-abdominal infections
  • Treatment of gynaecological infections such as endometritis and pelvic inflammatory disease
  • Treatment of skin and skin structure infections
  • Treatment of meningitis
  • Treatment of septicaemia
  • Pulmonary infections in cystic fibrosis
  • Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

  • Bactericidal action by interfering with bacterial cell wall synthesis
  • Potent bactericidal activity against a broad spectrum of Gram-positive and Gram-negative, aerobic and anaerobic bacteria

Dosage

  • Recommended daily dosage for adults and children
  • Different dosage for various types of infections and patient conditions
  • Dosage based on intravenous administration
  • Dosage based on weight for children
  • No experience in children with hepatic or renal impairment

Administration

  • Intravenous infusion over approximately 15-30 minutes
  • Intravenous bolus over approximately 3-5 minutes

Interaction

  • Competes with probenecid for active tubular secretion
  • Inhibits renal excretion, increasing elimination half-life and plasma concentration of meropenem
  • May reduce serum valproic acid levels

Contraindications

  • Hypersensitivity to the product

Side Effects

  • Inflammation at the site of injection
  • Thrombophlebitis
  • Skin reactions like rash, pruritus, and urticaria
  • Abdominal pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache

Pregnancy & Lactation

  • Pregnancy category B
  • No adequate and well-controlled studies in pregnant women
  • Caution should be exercised when administered to a nursing woman

Precautions & Warnings

  • Allergic reaction - discontinue if occurs
  • Use in patients with hepatic disease with careful monitoring of transaminase and bilirubin levels

Use in Special Populations

  • Dosage adjustments for renal impairment
  • No dosage adjustments for hepatic impairment
  • No dosage adjustments for elderly patients unless creatinine clearance is <51 ml/min
  • Efficacy and tolerability not established in infants under 3 months

Overdose Effects

  • Accidental overdose could occur, particularly in patients with renal impairment
  • Treatment should be symptomatic
  • Rapid renal elimination in normal individuals
  • Hemodialysis for removal in subjects with renal impairment

Therapeutic Class

  • Other beta-lactam Antibiotics

Reconstitution

  • Preparation of solution for intravenous bolus and infusion administration
  • Compatible infusion fluids for intravenous infusion administration
  • Freshly reconstituted solution recommended
  • Potency maintenance up to 3 hours at up to 25°C or 13 hours at up to 5°C

Storage Conditions

  • Store in a cool, dry place (below 30°C)
  • Away from light and moisture
  • Keep out of the reach of children

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