Sicmon 20 mg+20 mg (Tablet (Extended Release))

Unit Price: ৳ 9.00 (3 x 10: ৳ 270.00)
Strip Price: ৳ 90.00

Medicine Details

Category Details
Generic Pyridoxine hydrochloride doxylamine succinate
Company Navana pharmaceuticals ltd
Also available as
Sicmon 10 mg tablet

Indications

  • Treatment of nausea and vomiting of pregnancy
  • For women who do not respond to conservative management

Pharmacology

  • Doxylamine Succinate is an antihistamine
  • Blocks Histamine (H1) receptor
  • Crosses the blood brain barrier
  • High affinity for H1 receptors in the brain
  • Decreases the action of histamine at the H1 receptor
  • Inhibits both vestibular system & Muscarinic receptor
  • Affects the vestibular system
  • Decreases the stimulation of the vomiting center
  • Pyridoxine Hydrochloride is a vitamin B6 analog
  • Used to prevent nausea and vomiting
  • Antiemetic properties

Dosage & Administration

  • Take one tablet orally at bedtime on Day 1
  • If symptoms persist, increase the daily dose on Day 2
  • Maximum recommended dose is two tablets per day
  • Take on an empty stomach with a glass of water
  • Swallow tablets whole
  • Do not crush, chew, or split the tablets
  • Take daily and not on an as needed basis

Interaction

  • Contraindicated with monoamine oxidase inhibitors (MAOIs)
  • Not recommended with alcohol and other CNS depressants

Contraindications

  • Known hypersensitivity to Doxylamine Succinate or Pyridoxine Hydrochloride
  • Concurrent use of monoamine oxidase (MAO) inhibitors
  • Monoamine oxidase inhibitors intensify and prolong adverse effects

Side Effects

  • Somnolence
  • Accidents resulting from CNS depressants

Pregnancy & Lactation

  • Pregnancy category A
  • Excreted into breast milk
  • Caution should be exercised while breastfeeding

Precautions & Warnings

  • May cause somnolence
  • Avoid activities such as driving or operating heavy machinery
  • Not recommended with concurrent use of CNS depressants including alcohol
  • Use with caution in women with asthma, increased intraocular pressure, narrow angle glaucoma, stenosing peptic ulcer, pyloroduodenal obstruction or urinary bladder-neck obstruction

Overdose Effects

  • Signs and symptoms of intoxication may not be apparent immediately
  • Signs and symptoms may include restlessness, dryness of mouth, dilated pupils, sleepiness, vertigo, mental confusion, tachycardia
  • At toxic doses, exhibits anticholinergic effects including seizures, rhabdomyolysis, acute renal failure, death
  • Treatment consists of gastric lavage or activated charcoal, whole bowel irrigation, symptomatic treatment

Therapeutic Class

  • Anti-emetic drugs

Storage Conditions

  • Store at below 30°C in a dry place protected from light
  • Keep out of reach of children

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