Amitip 10 mg (Tablet)
Unit Price: ৳ 0.85 (10 x 10: ৳ 85.00)
Strip Price: ৳ 8.50
Medicine Details
| Category | Details |
|---|---|
| Generic | Amitriptyline hydrochloride |
| Company | Pacific pharmaceuticals ltd |
| Also available as |
Indications
- Depressive Illness
- Nocturnal Enuresis in children
- Prophylaxis of Migraine
- Tension Headache
- Chronic Pain
Description
- Tricyclic antidepressant
- Marked anticholinergic properties
- Sedative properties
- Prevents reuptake of noradrenaline and serotonin
- Rapidly absorbed from the GI tract
- Excreted in the urine
Pharmacology
- Inhibits the membrane pump mechanism
- Increases concentration of neurotransmitters
- Regulates mood
- Improves depressive symptoms
- Potential analgesic effects
- Unknown mechanism for analgesic effects
Dosage & Administration
- Initial dosage for depression
- Dosage for Nocturnal Enuresis in children
- Dosage for Prophylaxis of Migraine
- Dosage for Tension Headache
- Dosage adjustment for different age groups
- Maximum period of treatment for Nocturnal Enuresis
Interaction
- Enhancement of sedative effect by alcohol and opioid analgesics
- Increased risk of ventricular arrhythmias with specific drugs
- Inhibition of metabolism by Disulfiram and Cimetidine
- Enhanced risk of postural hypotension with diuretics
Contraindications
- Myocardial infarction
- Arrhythmias
- Mania
- Severe liver disease
- Initial sedation effect
- Impact on driving ability
Side Effects
- Anticholinergic effects
- Cardiovascular reactions
- CNS and Neuromuscular effects
- Allergic reactions
- Haematological effects
- Gastrointestinal effects
- Endocrine effects
Pregnancy & Lactation
- Pregnancy Category C
- Crosses placenta
- Excreted into breast milk
- Potential risk to fetus
- Impact on nursing infants
- Consideration for discontinuation
Precautions & Warnings
- Caution in patients with epilepsy
- Caution in patients with glaucoma
- Caution in patients with urinary retention
- Caution in patients with cardiac disease
- Caution in patients with diabetes
- Caution in patients with pregnancy
- Caution in patients with hepatic impairment
- Caution in patients with thyroid disease
- Caution in patients with increased intra-ocular pressure
- Caution in patients with psychoses
Therapeutic Class
- Tricyclic Anti-depressant
Storage Conditions
- Cool and dry storage
- Below 30°C
- Protection from light and moisture