Amitip 25 mg (Tablet)
Unit Price: ৳ 1.75 (5 x 10: ৳ 87.50)
Strip Price: ৳ 17.50
Medicine Details
| Category | Details |
|---|---|
| Generic | Amitriptyline hydrochloride |
| Company | Pacific pharmaceuticals ltd |
| Also available as |
Indications
- Depressive Illness
- Nocturnal Enuresis in children
- Prophylaxis of Migraine
- Tension Headache
- Chronic Pain
Description
- Tricyclic Antidepressant
- Marked anticholinergic properties
- Sedative properties
- Prevents reuptake of noradrenaline & serotonin
- Rapid absorption from GI tract
- Excreted in urine
Pharmacology
- Inhibits membrane pump mechanism
- Increases neurotransmitter concentration
- Regulates mood
- Counteracts monoamine deficiency
- Improves depressive symptoms
- Uncertain analgesic effects
Dosage & Administration
- Dosage for Depression
- Dosage for Nocturnal Enuresis
- Dosage for Prophylaxis of Migraine
- Dosage for Tension Headache
Interaction
- Enhances sedative effect of alcohol
- Enhances sedative effect of opioid analgesics
- Increased risk of ventricular arrhythmias with Moxifloxacin or Terfenadine
- Inhibited metabolism by Disulfiram and Cimetidine
- Enhanced risk of postural hypotension with diuretics
Contraindications
- Myocardial infarction
- Arrhythmias
- Mania
- Severe liver disease
- Initial sedation affecting ability to drive or operate machinery
Side Effects
- Anticholinergic effects
- Excessive perspiration
- Dry mouth
- Blurred vision
- Cardiovascular reactions
- Hypotension
- Syncope
- CNS and Neuromuscular effects
- Confusional states
- Disturbed concentration
- Allergic reactions
- Skin rash
- Urticaria
- Haematological effects
- Bone-marrow depression
- Gastrointestinal effects
- Nausea
- Endocrine effects
- Testicular swelling
- Gynaecomastia
- Breast enlargement
Pregnancy & Lactation
- Pregnancy Category C
- Crosses placenta
- Excreted into breast milk
- Serious adverse reactions in nursing infants
Precautions & Warnings
- Caution in patients with history of epilepsy
- Caution in patients with glaucoma
- Caution in patients with urinary retention
- Caution in patients with cardiac disease
- Caution in patients with diabetes
- Caution in patients with pregnancy
- Caution in patients with hepatic impairment
- Caution in patients with thyroid disease
- Caution in patients with increased intra-ocular pressure
- Caution in patients with psychoses
Therapeutic Class
- Tricyclic Antidepressant
Storage Conditions
- Store in a cool and dry place
- Below 30°C
- Protect from light and moisture