D-Best 200000 IU/ml (Injectable Solution (Oral & IM))
1 ml ampoule: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cholecalciferol vitamin d3 |
| Company | Pacific pharmaceuticals ltd |
| Also available as |
Indications
- Vitamin D3 deficiency
- Limited sunlight exposure
- Dietary deficiency
- Healthy bones and teeth
- Rickets prevention
- Osteomalacia prevention
- Osteoporosis prevention
- Pre-eclampsia prevention
- Immunity boost
Pharmacology
- Active form: Calcitriol
- Vitamin D receptors (VDRs) binding
- Fat-soluble
- Absorption in small intestine
- Metabolism to 25-hydroxy Vitamin D3
- Hydroxylation to 1,25-dihydroxy Vitamin D3
- Storage in tissues
- Elimination via faeces and urine
Dosage & Administration
- 40000 IU once weekly for 7 weeks
- 1400-2000 IU/day for maintenance therapy
- 20000 IU every 4 weeks for prevention
- 20000 IU once a month for osteoporosis
- 20000 IU once every 2 weeks for 6 weeks (12-18 years)
- 2000 IU/day (children's tablets)
- 400 IU/day for infants at risk of Cholecalciferol deficiency
- 2000 IU/day for Cholecalciferol deficient patients (0-18 yrs)
- Injection doses for prevention and deficiency
Interaction
- Magnesium containing Antacids
- Digoxin
- Thiazide Diuretics
- Cholestyramine
- Cholistipol
- Phenytoin
- Phenobarbital
- Orlistat
- Mineral Oil
- Corticosteroids (e.g. Prednisolone)
Contraindications
- Hypercalcaemia
- Hypersensitivity to Vitamin D3 or excipients
- Evidence of Vitamin D3 toxicity
Side Effects
- Anorexia
- Lassitude
- Nausea & vomiting
- Diarrhea
- Constipation
- Weight loss
- Polyuria
- Sweating
- Headache
- Thirst
- Vertigo
- Raised calcium and phosphate concentrations
Pregnancy & Lactation
- Safe use up to 4000 IU during pregnancy
- Recommended daily intake for pregnant women: 400 IU
- Excretion in breast milk
- No observed overdose in breast-fed infants
- Variability in requirements for pregnant women
Precautions & Warnings
- Monitoring plasma-calcium concentration
- Renal impairment
- Consultation for Digoxin and Thiazide Diuretics users
- Liver or kidney disease
- Primary hyperthyroidism
- Lymphoma
- Tuberculosis and granulomatous disease
Use in Special Populations
- Safety & efficacy not established in children under 12 years
Overdose Effects
- Hypervitaminosis D
Therapeutic Class
- Vitamin in bone formation
- Vitamin-D preparations
Storage Conditions
- Keep below 30°C
- Protected from light & moisture
- Keep out of the reach of children