Gigacef 125 mg/1.25 ml (Pediatric Drops)

Indications

• Treatment of infections caused by sensitive Gram-positive bacteria
• Treatment of infections caused by sensitive Gram-negative bacteria
• Upper respiratory tract infections
• Lower respiratory tract infections
• Urinary tract infections
• Skin and soft tissue infections
• Susceptibility to specific microorganisms

Pharmacology

• Semisynthetic broad spectrum bactericidal antibiotic
• Active against gram-positive and gram-negative microorganisms
• Inhibition of cell wall cross-linking process
• Lysis of bacteria due to external osmotic pressure

Dosage & Administration

• Recommended oral dosage for adults
• Recommended oral dosage for children
• Max daily dosage for adults
• Dosage for injectable administration in adults and children
• Appropriateness of normal adult dose for elderly
• Monitoring in patients with impaired renal or hepatic function

Interaction

• Increased risk of kidney damage with nephrotoxic drugs
• Enhanced renal toxicity with diuretics and probenecid

Contraindications

• Hypersensitivity to cephalosporins

Side Effects

• Gastro-intestinal disturbances
• Hypersensitivity phenomena
• Skin reactions
• Various rare side effects
• Possible blood and lymphatic system disorders
• Possible immune system disorders
• Possible psychiatric disorders
• Possible nervous system disorders
• Possible hepatobiliary disorders
• Possible renal and urinary disorders
• Possible elevated blood parameters

Pregnancy & Lactation

• Lack of teratogenicity evidence in animal studies
• Excretion in breast milk
• Caution in lactating mothers
• Caution about operating hazardous machinery

Precautions & Warnings

• Risk of superinfection with prolonged use
• Cross-sensitivity risk in patients hypersensitive to penicillins
• Potential positive Coombs' testing result
• Possibility of false positive urine glucose result
• Necessity of dosage adjustment in renal impairment
• Inappropriateness for patients with specific hereditary problems

Use in Special Populations

• Recommended doses for patients with renal impairment
• Additional dosing information for all patients
• Consideration for persistent infections
• Transfer considerations between therapy forms

Overdose Effects

• Non-specific symptoms
• Need for supportive treatment
• Necessity of gastric lavage for large ingestions

Therapeutic Class

• First generation Cephalosporins

Storage Conditions

• Fresh preparation of Gigacef Suspension
• Shelf life of reconstituted Suspension
• Shelf life of Injection solutions
• Retained potency at 5°C
• Variation in color of reconstituted solutions
• Dispensing on prescription

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