Hipre 10 mg (Tablet)
Unit Price: ৳ 7.00 (3 x 10: ৳ 210.00)
Strip Price: ৳ 70.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Amlodipine besilate |
| Company | Pacific pharmaceuticals ltd |
| Also available as |
Therapeutic Class
- Calcium-channel blockers
Indications
- Essential hypertension
- Angina pectoris
- Vasospastic angina
Pharmacology
- Amlodipine is a dihydropyridine calcium-channel blocker
- Long duration of action
- Influences myocardial cells
- Influences vascular smooth muscle
Dosage & Administration
- 5 mg once daily for hypertension
- 10 mg once daily maximum dose for hypertension
- 5 to 10 mg for angina
- Lower dose for elderly and hepatic insufficiency
- May be taken without regard to meals
Interaction
- Potentially hazardous interactions with p-blockers
- No interaction with Digoxin
- No interaction with Cimetidine
- No significant alteration with Warfarin
- Food does not alter the rate or extent of absorption
Contraindications
- Hypersensitivity to dihydropyridine derivatives
- Pregnant woman
Side Effects
- Dizziness
- Flushing
- Headache
- Hypotension
- Peripheral edema
- Gastrointestinal disturbances
- Increased micturition frequency
- Lethargy
- Eye pain
- Mental depression
- Paradoxical increase in ischaemic chest pain
- Excessive fall in blood pressure may lead to cerebral or myocardial ischaemia or transient blindness
- Rashes
- Fever
- Abnormalities in liver function due to hypersensitivity reaction
Pregnancy & Lactation
- Pregnancy Category C
- Adequate and well-controlled studies not available
- Use during pregnancy if potential benefit justifies the potential risk
Precautions & Warnings
- Precaution in patients with hepatic impairment
- Precaution during pregnancy and breast feeding
Use in Special Populations
- Usable in children with hypertension from 6 years to 17 years of age
- Elderly patients
- Renal impairment
- Hepatic impairment
Overdose Effects
- Excessive peripheral vasodilatation
- Reflex tachycardia
- Marked and prolonged systemic hypotension
- Shock with fatal outcome reported
- Management includes active cardiovascular support
- Monitoring of cardiac and respiratory function
- Elevation of extremities
- Attention to circulating fluid volume and urine output
- Possible use of vasoconstrictor
- Intravenous calcium gluconate may be beneficial
- Gastric lavage may be worthwhile
Storage Conditions
- Keep all medicines out of reach of children
- Store in a cool & dry place
- Protected from light