Hypezide 50 mg (Tablet)

Unit Price: ৳ 1.00 (10 x 10: ৳ 100.00)
Strip Price: ৳ 10.00

Medicine Details

Indications

  • Edema associated with congestive heart failure
  • Edema associated with hepatic cirrhosis
  • Edema associated with premenstrual tension
  • Edema due to various forms of renal dysfunction
  • Hypertension treatment

Pharmacology

  • Promotes water loss from the body
  • Inhibits Na/Cl reabsorption in the kidneys
  • Causes loss of potassium
  • Increases serum uric acid
  • Prevents hypertension-related morbidity and mortality
  • Causes vasodilation
  • Activates calcium-activated potassium channels
  • Inhibits various carbonic anhydrases in vascular tissue

Dosage & Administration

  • Initial dose for edema: 25 to 50 mg daily
  • Maximum dose for edema: 100 mg daily
  • Dose for hypertension: 25 mg daily, increased to 50 mg if necessary
  • Initial elderly dose: 12.5 mg daily
  • Initial children's dose: 1 to 2 mg per kg body-weight in 2 divided doses

Interaction

  • Potential potentiation of orthostatic hypotension with alcohol, barbiturates, or narcotics
  • Possible adjustment of dosage with concurrent use of oral and parenteral antidiabetic drugs
  • Additive effect with other antihypertensive drugs
  • Reduced absorption in the presence of cholestyramine and colestipol resin
  • Possible interaction with corticosteroids or ACTH intensifying electrolyte depletion
  • Attenuation of diuretic and antihypertensive effects with non-steroidal anti-inflammatory drugs

Contraindications

  • Anuria
  • Hypersensitivity to Hydrochlorothiazide or other sulphonamide-derived drugs
  • Severe renal or hepatic failure
  • Addison’s disease
  • Hypercalcemia
  • Concurrent lithium therapy

Side Effects

  • Gastrointestinal effects: anorexia, nausea, vomiting, diarrhea, jaundice, pancreatitis
  • Central nervous system effects: dizziness, paraesthesiae, headache
  • Hematological effects: leucopenia, thrombocytopenia, anemia
  • Cardiovascular effects: hypotension, orthostatic hypotension
  • Hypersensitivity reactions: purpura, rash, urticaria, fever, respiratory distress
  • Metabolic effects: hyperglycemia, electrolyte imbalance
  • Renal effects: renal dysfunction, interstitial nephritis
  • Other effects: muscle spasm, weakness, blurred vision, impotence

Pregnancy & Lactation

  • Thiazides cross the placental barrier
  • Use in pregnancy requires weighing of benefits and possible hazards
  • Not recommended in otherwise healthy pregnant women
  • Thiazides appear in breast milk

Precautions & Warnings

  • Monitoring for signs of fluid and electrolyte imbalance
  • Warning signs or symptoms of imbalance
  • Precautions for hypokalaemia
  • Sensitivity reactions may occur
  • Considerations for impaired renal function
  • Caution in patients with impaired hepatic function or progressive liver disease
  • Potential for hyperuricaemia, gout, and impaired glucose tolerance
  • Possibility of exacerbation or activation of systemic lupus erythematosus

Overdose Effects

  • Electrolyte depletion
  • Dehydration
  • Possible accentuation of cardiac arrhythmias due to hypokalaemia
  • Symptomatic and supportive measures required
  • Emesis or gastric lavage for recent ingestion
  • Correction of dehydration, electrolyte imbalance, hepatic coma, and hypotension

Therapeutic Class

  • Thiazide diuretics & related drugs

Storage Conditions

  • Below 30°C temperature
  • Away from light & moisture
  • Keep out of the reach of children

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