Aldonist 50 mg (Tablet)

Indications

• Congestive heart failure after an acute myocardial infarction
• Hypertension

Pharmacology

• Eplerenone selectively binds to the mineralocorticoid receptor and blocks the binding of aldosterone
• Regulation of BP and pathophysiology of CV disease

Dosage & Administration

• Recommended dose of Eplerenone is 50 mg once daily
• May be administered with or without food
• Starting dose for hypertension is 50 mg administered once daily
• Dosage may be increased to 50 mg twice daily if inadequate blood pressure response

Interactions

• May increase risk of hyperkalaemia with ACE inhibitors and/or angiotension receptor blocker
• May reduce antihypertensive effect with NSAIDs, glucocorticoids
• May enhance hypotensive effect of α1-blockers, TCAs, amifostine, baclofen, neuroleptics
• May increase plasma level with mild to moderate CYP3A4 inhibitors

Contraindications

• Hyperkalaemia
• Severe renal impairment (creatinine clearance less than 30 ml/min)
• Severe hepatic impairment
• Concomitant use with potent CYP3A4 inhibitors
• Potassium-sparing diuretics

Side Effects

• Headache
• Dizziness
• Diarrhea
• Stomach pain
• Nausea
• Cough or flu-like symptoms
• Symptoms of a serious allergic reaction like rash, itching, swelling

Pregnancy & Lactation

• No adequate and well-controlled studies in pregnant women
• Eplerenone should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus
• Concentration of Eplerenone in human breast milk after oral administration is unknown

Precautions & Warnings

• Use with caution in hyperkalemia, severe kidney disease, diabetic patients with congestive heart failure after an acute myocardial infarction including those with proteinuria

Use in Special Populations

• Safety and effectiveness not established in pediatric patients
• No differences in overall incidence of effectivity or safety observed in elderly patients

Overdose Effects

• Symptoms: Hyperkalaemia, hypotension
• Management: Symptomatic and supportive treatment
• Administer activated charcoal
• Initiate standard therapy for hyperkalaemia

Therapeutic Class

• Potassium-sparing diuretics
• Aldosterone antagonists

Storage Conditions

• Store below 30°C in a cool and dry place
• Protected from light and moisture
• Keep out of children’s reach

Related Brands

• Aldonist 25 mg (Tablet) - unimed-unihealth-pharmaceuticals-ltd