Linadi Plus 2.5 mg+500 mg (Tablet)
Unit Price: ৳ 12.00 (10 x 3: ৳ 360.00)
Strip Price: ৳ 36.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Linagliptin metformin hydrochloride |
| Company | Pacific pharmaceuticals ltd |
| Also available as |
Therapeutic Class
- Oral hypoglycemic preparations
Indications
- Adjunct to diet and exercise
- Improves glycemic control
- Type 2 diabetes mellitus treatment
Pharmacology
- Inhibitor of DPP-4 enzyme
- Increases concentration of active incretin hormones
- Stimulates insulin release
- Decreases glucagon secretion
Dosage & Administration
- Individualized dosage based on effectiveness and tolerability
- Maximum recommended dose of 2.5 mg Linagliptin and 1000 mg Metformin Hydrochloride twice daily with meals
- Gradual dose escalation to reduce gastrointestinal side effects
- Different dosage for immediate release and extended release tablets
- Dose adjustment for patients with renal impairment
Interaction
- Potential interaction with cationic drugs
- Contraindication with carbonic anhydrase inhibitors
- Effects of inducers of P-glycoprotein and CYP3A4 enzymes
- Potential effects of drugs affecting glycemic control
Contraindications
- Contraindicated in renal impairment
- Contraindicated in acute or chronic metabolic acidosis
- Contraindicated in hypersensitivity to Linagliptin or Metformin Hydrochloride
Side Effects
- Common side effects include nasopharyngitis and diarrhea
- Increased risk of hypoglycemia in combination with sulfonylureas
Pregnancy & Lactation
- Limited data in pregnant women
- Use during pregnancy only if clearly needed
- Caution during lactation
Precautions & Warnings
- Discontinue in case of lactic acidosis or pancreatitis
- Monitoring of Vitamin B12 levels
- Instructions for alcohol consumption and other medicines
- Guidance for counseling, travel, and emergencies
- Risk of hypoglycemia
Overdose Effects
- Supportive measures for overdose
- Dialyzable nature of Metformin Hydrochloride
- Lack of dose-related adverse drug reactions in controlled trials
Storage Conditions
- Storage below 30°C
- Protection from light and moisture
- Keep out of the reach of children