Linadi Plus 2.5 mg+500 mg (Tablet)

Unit Price: ৳ 12.00 (10 x 3: ৳ 360.00)
Strip Price: ৳ 36.00

Medicine Details

Category Details
Generic Linagliptin metformin hydrochloride
Company Pacific pharmaceuticals ltd
Also available as
Linadi plus 25 mg tablet Linadi plus 25 mg tablet

Therapeutic Class

  • Oral hypoglycemic preparations

Indications

  • Adjunct to diet and exercise
  • Improves glycemic control
  • Type 2 diabetes mellitus treatment

Pharmacology

  • Inhibitor of DPP-4 enzyme
  • Increases concentration of active incretin hormones
  • Stimulates insulin release
  • Decreases glucagon secretion

Dosage & Administration

  • Individualized dosage based on effectiveness and tolerability
  • Maximum recommended dose of 2.5 mg Linagliptin and 1000 mg Metformin Hydrochloride twice daily with meals
  • Gradual dose escalation to reduce gastrointestinal side effects
  • Different dosage for immediate release and extended release tablets
  • Dose adjustment for patients with renal impairment

Interaction

  • Potential interaction with cationic drugs
  • Contraindication with carbonic anhydrase inhibitors
  • Effects of inducers of P-glycoprotein and CYP3A4 enzymes
  • Potential effects of drugs affecting glycemic control

Contraindications

  • Contraindicated in renal impairment
  • Contraindicated in acute or chronic metabolic acidosis
  • Contraindicated in hypersensitivity to Linagliptin or Metformin Hydrochloride

Side Effects

  • Common side effects include nasopharyngitis and diarrhea
  • Increased risk of hypoglycemia in combination with sulfonylureas

Pregnancy & Lactation

  • Limited data in pregnant women
  • Use during pregnancy only if clearly needed
  • Caution during lactation

Precautions & Warnings

  • Discontinue in case of lactic acidosis or pancreatitis
  • Monitoring of Vitamin B12 levels
  • Instructions for alcohol consumption and other medicines
  • Guidance for counseling, travel, and emergencies
  • Risk of hypoglycemia

Overdose Effects

  • Supportive measures for overdose
  • Dialyzable nature of Metformin Hydrochloride
  • Lack of dose-related adverse drug reactions in controlled trials

Storage Conditions

  • Storage below 30°C
  • Protection from light and moisture
  • Keep out of the reach of children

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