Linadi Plus 2.5 mg+1000 mg (Tablet)
Unit Price: ৳ 16.00 (2 x 10: ৳ 320.00)
Strip Price: ৳ 160.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Linagliptin metformin hydrochloride |
| Company | Pacific pharmaceuticals ltd |
| Also available as |
Indications
- Improves glycemic control in adults with type 2 diabetes mellitus
Pharmacology
- Inhibitor of DPP-4 enzyme
- Stimulates insulin release
- Decreases glucagon secretion
- Lowers plasma glucose
- Improves insulin sensitivity
Dosage & Administration
- Individualized dosage based on effectiveness and tolerability
- Maximum recommended dose of 2.5 mg Linagliptin and 1000 mg Metformin Hydrochloride twice daily with meals
- Gradual dose escalation to reduce gastrointestinal side effects
- Dosage guidance for different patient scenarios
Interaction
- Potential interaction with cationic drugs
- Risk of metabolic acidosis with carbonic anhydrase inhibitors
- Effect on Linagliptin exposure with inducers of P-glycoprotein and CYP3A4 enzymes
- Impact of certain drugs on glycemic control
Contraindications
- Contraindicated in patients with renal impairment
- Acute or chronic metabolic acidosis
- Hypersensitivity to Linagliptin or Metformin Hydrochloride
Side Effects
- Common side effects include nasopharyngitis and diarrhea
- Increased risk of hypoglycemia with sulfonylureas
Pregnancy & Lactation
- Limited studies in pregnant women
- Caution advised during pregnancy and lactation
Precautions & Warnings
- Discontinue in case of lactic acidosis
- Postmarketing reports of acute pancreatitis
- Monitoring of Vitamin B12 levels
- Symptoms and precautions for lactic acidosis
- Guidance for alcohol, other medicines, counseling, travel, and emergencies
- Risk of hypoglycemia and its symptoms
Overdose Effects
- Supportive measures for overdose
- Removal of unabsorbed material from gastrointestinal tract
- Hemodialysis or peritoneal dialysis for Metformin Hydrochloride overdose symptoms
- No dose-related adverse reactions with Linagliptin overdose
- Hypoglycemia and lactic acidosis with Metformin Hydrochloride overdose
Therapeutic Class
- Combination oral hypoglycemic preparations
Storage Conditions
- Keep in a cool & dry place
- Protected from light & moisture
- Keep out of the reach of children
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