Odatron 8 mg (Tablet)
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ondansetron |
| Company | Pacific pharmaceuticals ltd |
| Also available as |
Product Title
- Odatron Oral Soluble Film
Categories
- Medicine
- Anti-emetic drugs
Description
- Oral soluble film designed for application on top of the tongue
- Does not require water to aid dissolution or swallowing
- Contains Odatron base, a selective blocking agent of the serotonin 5-HT3 receptor type
- Empirical formula: C18H19N3O, molecular weight: 293.3
Indications and Usage
- Prevents nausea and vomiting associated with emetogenic cancer chemotherapy
- Prevents and treats post-operative nausea and vomiting
- Prevents radiotherapy-induced nausea and vomiting
Dosage Forms and Strengths
- 8 mg oral soluble film
- 4 mg oral soluble film
- Injection
Dosage Information
- Dosage varies for different age groups and conditions as per medical advice
Mode of Action
- Potent, highly selective 5HT3 receptor-antagonist
- Blocks initiation of vomiting reflex by activating vagal afferents via 5HT3 receptors
- Likely antagonizes 5HT3 receptors on neurons in both peripheral and central nervous systems
Administration Instructions
- Tear the pouch carefully along the edge tear mark
- Place the film on top of the tongue where it will dissolve within 20 seconds
- Do not chew or swallow the film whole
- Swallow after the film dissolves, with or without liquid
- Wash hands after taking the film
Interaction Information
- Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes
- Inducers or inhibitors of these enzymes may change the clearance and half-life of Odatron
Contraindications
- Hypersensitivity to the drug or any of its components
- Concomitant use of apomorphine
Side Effects
- Frequently reported events: headache, constipation, diarrhea, rash
- Rare adverse events: anaphylaxis, brochospasm, tachycardia, chest pain, hypokalemia, shortness of breath
- Reports of flushing or warmth, hiccups, liver enzyme abnormalities
Pregnancy and Lactation
- No evidence of impaired fertility or harm to the fetus in animal studies
- Excreted in the breast milk of rats
- Caution advised during nursing
Precautions and Warnings
- Hypersensitivity reactions reported in patients with hypersensitivity to other selective 5-HT3 receptor antagonists
- Should not be used instead of nasogastric suction
- May mask progressive ileus and/or gastric distension in certain patients
Special Populations
- Dosage adjustment for patients with impaired hepatic function
- Limited information on dosage for pediatric patients 4 years of age or younger
Therapeutic Class
- Anti-emetic drugs
Storage Conditions
- Store at temperature not exceeding 30°C in a dry place
- Protect from light and moisture