Panfre Plus 50 mg+200 mcg (Tablet)

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)

Strip Price: ৳ 100.00

Medicine Details

Category	Details
Generic	Diclofenac sodium misoprostol
Company	Pacific pharmaceuticals ltd

Indications

Treatment of osteoarthritis
Treatment of rheumatoid arthritis in high-risk patients

Pharmacology

Contains Diclofenac Sodium and Misoprostol
NSAID with analgesic properties
Gastrointestinal mucosal protective prostaglandin E 1 analog
Inhibition of prostaglandin synthesis
Increase in bicarbonate and mucous production
Prevention of gastric and duodenal ulcers

Dosage & Administration

Recommended dosage for osteoarthritis
Recommended dosage for rheumatoid arthritis
Maximal GI mucosal protection dosage
Dosage adjustments for intolerant patients

Interaction

Contraindications with aspirin
Elevated digoxin levels
Inhibition of antihypertensives
Synergistic effects with warfarin
Effects on oral hypoglycaemics
Reduction of bioavailability by antacids
Inhibition of diuretic activity

Contraindications

Hypersensitivity to Diclofenac and Misoprostol
Contraindicated in asthma and urticaria patients

Side Effects

Abdominal pain
Diarrhea
Other GI symptoms
Rare instances of severe dehydration with diarrhea

Pregnancy & Lactation

Abortifacient property of Misoprostol
Presence of Diclofenac Sodium in nursing mothers' milk

Precautions & Warnings

Monitoring for patients with underlying conditions
Monitoring for dehydration

Use in Special Populations

Paediatric use not established
No overall differences in geriatric use observed

Overdose Effects

Misoprostol overdose effects
Diclofenac overdose effects
Supportive treatment for management

Therapeutic Class

Drugs for Osteoarthritis
Drugs used for Rheumatoid Arthritis
Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Storage Conditions

Cool and dry storage below 25°C
Protection from light

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