Spiretic 25 mg (Tablet)
Unit Price: ৳ 5.05 (3 x 10: ৳ 151.50)
Strip Price: ৳ 50.50
Medicine Details
| Category | Details |
|---|---|
| Generic | Spironolactone |
| Company | Drug international ltd |
Indications
- Congestive heart failure
- Hepatic cirrhosis with ascites and oedema
- Nephrotic syndrome
- Primary hyperaldosteronism
- Essential hypertension
- Treatment of patients with hypokalemia
Description
- Long-acting aldosterone antagonist
- Specific pharmacologic antagonist of aldosterone
- Competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site
- Causes increased excretion of sodium and water
- Retains potassium and magnesium
Pharmacology
- Acts as a diuretic
- Acts as an antihypertensive
- Binds to mineralocorticoid receptor
- Blocks actions of aldosterone on gene expression
- Retains sodium and excretes potassium in the kidneys
Dosage & Administration
- Initial daily dosage of 100 mg
- May range from 25 to 200 mg daily
- Combined therapy with other diuretics
- Doses of 100 to 400 mg daily for hyperaldosteronism
- Initial daily dosage of 50 to 100 mg for hypertension
- Useful in treating diuretic-induced hypokalemia
Interactions
- Concomitant administration of ACE inhibitors
- Potentiation of orthostatic hypotension with alcohol, barbiturates, or narcotics
- Intensified electrolyte depletion with corticosteroids, ACTH
- Reduced renal clearance and high risk of toxicity with lithium
- Increases the half-life of digoxin
Contraindications
- Acute renal insufficiency
- Significant impairment of renal function
- Anuria
- Hyperkalaemia
- Sensitivity to Spironolactone
Side Effects
- Gynaecomastia
- GI symptoms including cramping and diarrhoea
- Drowsiness
- Lethargy
- Headache
- Urticaria
- Mental confusion
- Impotence
- Irregular menses
- Amenorrhoea
- Post-menopausal bleeding
Pregnancy & Lactation
- Not to be used during pregnancy
- Canrenone, an active metabolite, appears in breast milk
Precautions & Warnings
- Observation for evidence of fluid or electrolyte imbalance
- Hyperkalemia may occur in patients with impaired renal function or excessive potassium intake
Overdose Effects
- Symptoms of drowsiness, mental confusion, dizziness, diarrhea, and vomiting
- Induce vomiting or evacuate the stomach by lavage
Therapeutic Class
- Potassium-sparing diuretics
- Aldosterone antagonists
Storage Conditions
- Store in a cool and dry place protected from light
- Keep out of reach of children