Panfre 75 mg/3 ml (IM Injection)
3 ml ampoule: ৳ 15.00 (2 x 5: ৳ 150.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Diclofenac sodium |
| Company | Pacific pharmaceuticals ltd |
| Also available as |
Indications
- Inflammatory and degenerative forms of rheumatism
- Chronic involutive
- Polyarthritis
- Ankylosing spondylarthritis
- Osteoarthritis
- Spondylarthroses
- Acute gout
- Peri-articular rheumatic disorders
- Sprain
- Bruises
- Dislocations
- Fractures
- Soft tissue injuries
- Surgical interventions
- Primary dysmenorrhoea
- Episiotomy
- Adnexitis
- Endometritis
- Parametritis
- Salpingitis
- Mastitis
- Pre-operative medication for the prevention of pain, inflammation, and swelling
- Post-operative and post-traumatic pain, inflammation, and swelling
- Prevention of pain and treatment of inflammation and swelling of patients operated in the urogenital tract
- Renal and biliary colic
Pharmacology
- Non-steroidal anti-inflammatory drug
- Anti-rheumatic
- Analgesic
- Antipyretic
- Uricosuric effect
- Inhibition of prostaglandin biosynthesis
- Rapid and complete absorption from the gastro-intestinal tract
- Peak plasma concentrations reached within an average of 2 hours after ingestion
- 99.7% bound to plasma proteins
- Metabolized in the liver
- Undergoes first pass metabolism
Dosage & Administration
- Adult dosage of 75-150 mg daily in 2 to 3 divided doses
- Children dosage of 1-3 mg of diclofenac/kg body weight daily in divided doses
- Elderly patients recommended lowest effective dosage
- Maximum daily dose of 150 mg
- Capsule dosage of one capsule daily
- Suppository dosage of 50 mg 2-3 times daily
- Gel dosage of 2-4 g applied to the skin 3-4 times daily
Interactions
- Increased plasma concentrations of lithium and digoxin
- Increased risk of hemorrhage with combined use of diclofenac and anticoagulant therapy
- No influence on antidiabetic agents' clinical effect
- Reported nephrotoxicity with concomitant use of cyclosporin
- Serious toxicity reported when methotrexate and NSAIDs given within 24 hours of each other
- Potential convulsions due to interaction between quinolones and NSAIDs
- Increased frequency of unwanted effects with co-administration of diclofenac with other systemic NSAIDs and steroids
Contraindications
- Hypersensitivity to any ingredient of the products
- Peptic ulcer
- Hypersensitivity to Diclofenac like other non-steroid anti-inflammatory agents
- Contra-indicated in asthmatic patients in whom attack with asthma, urticaria or acute rhinitis are precipitated by acetylsalicylic acid or by other drugs with prostaglandin synthetase inhibitor
Side Effects
- Mild, rare, and transient adverse effects
- Epigastric pain
- Eructation
- Nausea
- Diarrhea
- Dizziness
- Headache
- Peripheral edema
- Skin reactions such as rash and eczema
- Local irritation and reddening of the skin
- Skin rash
Pregnancy & Lactation
- Employed only for compelling reasons during pregnancy
- Lowest effective dose should be used
- Not recommended during the first trimester of pregnancy
- Not recommended during pregnancy due to insufficient clinical data
- Insignificant quantity detected in breast milk
Precautions & Warnings
- Close observation in rare instances of peptic ulceration or gastrointestinal bleeding
- Close observation in patients with advanced age
- Avoid contact with eyes or mucous membranes
- Proper hand washing after application
- Not to be taken by mouth
Therapeutic Class
- Drugs for Osteoarthritis
- Drugs used for Rheumatoid Arthritis
- Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Storage Conditions
- Store in a cool and dry place
- Protected from light
- Store below 30°C
- Keep out of the reach of children