Spirocard 25 mg (Tablet)
Unit Price: ৳ 5.50 (10 x 10: ৳ 550.00)
Strip Price: ৳ 55.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Spironolactone |
| Company | Popular pharmaceuticals ltd |
| Also available as |
Indications
- Congestive heart failure
- Hepatic cirrhosis with ascites and oedema
- Nephrotic syndrome
- Primary hyperaldosteronism
- Essential hypertension
- Treatment of patients with hypokalemia
Description
- Long-acting aldosterone antagonist
- Specific pharmacologic antagonist of aldosterone
- Competitive binding of receptors at aldosterone dependent sodium-potassium exchange site
- Causes increased excretion of sodium and water
- Retention of potassium and magnesium
Pharmacology
- Acts as a diuretic and antihypertensive drug
- Interacts with a cytoplasmic mineralocorticoid receptor
- Enhances the expression of Na+ K+ ATPase and Na+ channel
- Blocks the actions of aldosterone on gene expression
- Hormonal function is to retain sodium and excrete potassium in the kidneys
Dosage & Administration
- Initial daily dosage of 100 mg
- May range from 25 to 200 mg daily
- Combined therapy with other diuretics
- Doses of 100 to 400 mg daily in hyperaldosteronism
- Initial daily dosage of 50 to 100 mg for essential hypertension
- Ranging from 25 mg to 100 mg daily for hypokalemia
Interaction
- Concomitant administration with ACE inhibitors may cause severe hyperkalemia
- Potentiation of orthostatic hypotension with alcohol, barbiturates, or narcotics
- Intensified electrolyte depletion with corticosteroids or ACTH
- Avoid concomitant use with lithium due to increased risk of toxicity
- Increases the half-life of digoxin
Contraindications
- Acute renal insufficiency
- Significant impairment of renal function
- Anuria
- Hyperkalaemia
- Sensitivity to Spironolactone
Side Effects
- Gynaecomastia
- GI symptoms including cramping and diarrhoea
- Drowsiness
- Lethargy
- Headache
- Urticaria
- Mental confusion
- Impotence
- Irregular menses or amenorrhoea
- Post-menopausal bleeding
Pregnancy & Lactation
- Not recommended during pregnancy
- Active metabolite appears in breast milk
Precautions & Warnings
- Observation for evidence of fluid or electrolyte imbalance
- Risk of hyperkalemia in patients with impaired renal function or excessive potassium intake
Overdose Effects
- Drowsiness
- Mental confusion
- Dizziness
- Diarrhea
- Vomiting
- Induce vomiting or stomach lavage in case of overdose
Therapeutic Class
- Potassium-sparing diuretics
- Aldosterone antagonists
Storage Conditions
- Store in a cool and dry place protected from light
- Keep out of reach of children