Alphin DS 400 mg (Chewable Tablet)
Unit Price: ৳ 5.00 (5 x 10: ৳ 250.00)
Strip Price: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Albendazole |
| Company | Beximco pharmaceuticals ltd |
Indications
- Single infestations of hookworm (Ancylostoma)
- Mixed infestations of roundworm (Ascaris), threadworm (Enterobius), whipworm (Trichuris), strongyloides, tapeworm, opisthorchi, hydatid
Description
- Benzimidazole anthelmintic
- Active against most nematodes and some cestodes
- Used in the treatment of intestinal nematode infections
- Used in higher doses for the treatment of hydatid disease
- Exhibits vermicidal, ovicidal, and larvicidal activity
- Inhibits tubulin polymerization resulting in the loss of cytoplasmic microtubules
Pharmacology
- Broad spectrum anthelmintic
- Exhibits vermicidal, ovicidal, and larvicidal activities
- Blocks glucose uptake in susceptible helminths, depleting energy level for survival
- Binds and inhibits parasite tubulin polymerization
- Extensively metabolized, likely in the liver
- Poorly absorbed from the gastrointestinal tract
Dosage & Administration
- 400 mg (1 tablet or 10 ml suspension) as a single dose for various infections
- Daily doses for strongyloidiasis or taeniasis for 3 consecutive days
- Recommended single dose for children of 1-2 years: 200 mg (5 ml suspension)
- Not recommended for children under 1 year
- Dose for hydatid disease (Echinococcosis) varies based on patient weight
- 5-day treatment course for giardiasis
Interaction
- No reported pharmacodynamic or pharmacokinetic interactions
Contraindications
- Not normally used in neonates
- Dose reduction may be indicated in children weighing less than 10 kg
- Not recommended during pregnancy or for women thought to be pregnant
- No evidence to alter dose in renal, hepatic, or cardiac failure
Side Effects
- Gastrointestinal disturbances
- Headache
- Dizziness
- Changes in liver enzymes
- Rarely reversible alopecia
- Rash
- Fever
- Blood disorders including leucopenia and pancytopenia
- Allergic shock if cyst leakage
- Convulsion and meningism in cerebral disease
Pregnancy & Lactation
- US FDA Pregnancy category of Albendazole is C
- Avoid in pregnancy and lactation unless benefits outweigh risks to the fetus
Precautions & Warnings
- Blood counts and liver function tests before treatment and twice during each cycle
- Breastfeeding
- Exclude pregnancy before starting treatment
- Constant medical supervision and monitoring for Echinococcosis treatment
Therapeutic Class
- Anthelmintic
Storage Conditions
- Keep in a dry place
- Away from light and heat
- Keep out of the reach of children