Tobram 0.3% (Ophthalmic Solution)

5 ml drop: ৳ 100.00

Medicine Details

Category Details
Generic Tobramycin ophthalmic
Company Pacific pharmaceuticals ltd

Indications

  • Treatment of external bacterial infections of the eye caused by susceptible organisms
  • Effective against Gram-positive bacteria: Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus spp. of group A beta-hemolytic and some nonhemolytic species
  • Effective against Gram-negative bacteria: E.coli, Pseudomonas aeruginosa, Enterobacter aerogenes, Klebsiella spp., Proteusmirabillis, Proteus vulgaris, Haemophilus influenzae, Morganella morganii, Acinetobacter calcoaceticus, Providentia, Serratia, Salmonella spp and some strains of Neisseria

Pharmacology

  • Bactericidal activity
  • Binds to the 30s and to some extent to the 50s subunits of the bacterial ribosome
  • Inhibits protein synthesis
  • Generates errors in the transcription of the genetic code
  • Imperfectly understood manner of cell death
  • Possible effects on membrane permeability

Dosage & Administration

  • Mild to moderate infection: apply a small amount 2-3 times daily into the conjunctival sac(s)
  • Severe cases of infection: apply a small amount 3-4 times daily into the conjunctival sac(s) until improvement is obtained, then reduce the dose gradually
  • Mild to moderate infections: Instill 1 or 2 drops into the affected eye(s) every 4 hours
  • Severe infections: Instill 2 drops into the affected eye(s) every hour until improvement is observed
  • Pediatric use: Safety and effectiveness in children below the age of 1 year have not been established

Interaction

  • Care should be exercised when given to patients receiving other drugs with neuromuscular blocking agents or ototoxic

Contraindications

  • Hypersensitivity to Tobramycin or any of the ingredients of the preparation

Side Effects

  • Localized ocular toxicity
  • Conjunctival erythema
  • Hypersensitivity including lid itching and swelling

Pregnancy & Lactation

  • Pregnancy Category B
  • No adequate and well-controlled studies in pregnant women
  • Drug excreted into human milk
  • A decision should be made whether to discontinue nursing or to take the drug

Precautions & Warnings

  • Minor sensitivity may occur to topically applied aminoglycosides in some patients
  • Discontinue use if a sensitivity reaction occurs
  • Prolonged use may result in overgrowth of nonsusceptible organisms and fungi

Overdose Effects

  • Signs and symptoms of overdose may be similar to side effects

Therapeutic Class

  • Ophthalmic antibacterial drugs

Storage Conditions

  • Protect from light
  • Store in cool (below 25°C) & dry place
  • Keep out of reach of children
  • Use within 4 weeks after first opening

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