Tobram-D 0.1%+0.3% (Ophthalmic Solution)

5 ml drop: ৳ 150.00

Medicine Details

Category Details
Generic Dexamethasone tobramycin
Company Pacific pharmaceuticals ltd

Title and Categories

  • Tobram-D Ophthalmic Solution
  • Ophthalmic Medication
  • Ophthalmic Steroid-Antibiotic Combination

Indications

  • Steroid-responsive inflammatory ocular conditions
  • Chronic anterior uveities
  • Corneal injury from chemical, radiation, or thermal burns
  • Penetration of foreign bodies

Pharmacology

  • Bactericidal activity of Tobramycin
  • Inhibition of normal protein synthesis in susceptible bacteria
  • Inhibition of phospholipase A2 by Dexamethasone
  • Inhibition of chemo-tactic infiltration of neutrophils by Dexamethasone

Dosage and Administration

  • 1 drop into conjunctival sac 3-5 times per day (Eye Drops)
  • 1 drop every 2 hours for 24-48 hours (Initial dosage)
  • Apply small amount into conjunctival sac 3-4 times per day (Eye Ointment)
  • Pediatric use below 2 years not established

Interaction

  • No specific interaction studies conducted with Tobram-D eye drops
  • Interval of 10 minutes recommended between successive applications if therapy with other topical ophthalmic medicines is concomitant

Contraindications

  • Epithelial herpes simplex keratitis
  • Vaccinia
  • Varicella
  • Mycobacterial infection of the eye
  • Hypersensitivity to any component of the medication

Side Effects

  • Hypersensitivity
  • Localized ocular toxicity
  • Elevation of intraocular pressure
  • Optic nerve damage
  • Posterior subcapsular cataract formation
  • Delayed wound healing

Pregnancy and Lactation

  • No adequate and well-controlled studies in pregnant women
  • Use during pregnancy justified only if potential benefit exceeds potent risk to fetus
  • Caution during nursing due to unknown systemic absorption in human milk

Precautions and Warnings

  • Consider possibility of fungal infections after long-term steroid dosing
  • Prolonged use may result in overgrowth of non-susceptible organisms
  • Cross-sensitivity to other aminoglycoside antibiotics may occur

Overdose Effects

  • Overdose through local administration not known
  • Specific measures to reduce resorption in case of accidental oral intake
  • No specific antidote available

Therapeutic Class

  • Ophthalmic steroid-antibiotic combined preparations

Storage Conditions

  • Store at room temperature
  • Close bottle immediately after use
  • Do not use for longer than one month after opening

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