Tofator 5 mg (Tablet)
Unit Price: ৳ 35.00 (1 x 10: ৳ 350.00)
Strip Price: ৳ 350.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tofacitinib |
| Company | Square pharmaceuticals plc |
Indications
- Rheumatoid Arthritis
- Psoriatic Arthritis
- Ulcerative Colitis
Pharmacology
- Autoimmune disease
- Pro-inflammatory cytokines
- Janus kinase signalling pathway
- JAK-STAT pathway
- Immune cell function
Dosage & Administration
- Tofacitinib 5 mg twice daily
- Tofacitinib 11 mg once daily
- Recommended dosage for renal impairment or moderate hepatic impairment
Interaction
- Potent inhibitors of Cytochrome P450 3A4 (CYP3A4)
- Concomitant medications with moderate inhibition of CYP3A4 and potent inhibition of CYP2C19
- Potent CYP inducers
Side Effects
- Upper respiratory tract infections
- Headache
- Diarrhea
- Nasopharyngitis
Pregnancy & Lactation
- Pregnancy Category C
- Use during pregnancy if potential benefit justifies potential risk to fetus
- Excretion in human milk
Precautions & Warnings
- Avoid use during active serious infection
- Use with caution in patients at increased risk of gastrointestinal perforations
- Recommended laboratory monitoring
- Avoid use with live vaccines
- Absolute lymphocyte count, absolute neutrophil count, hemoglobin thresholds
Use in Special Populations
- Pediatric use
- Geriatric use
- Renal impairment or hepatic impairment
Therapeutic Class
- Immunosuppressant
Storage Conditions
- Store below 30°C
- Protect from light & moisture
- Keep out of the reach of children
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