Tridyl 5 mg (Tablet)
Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Trihexyphenidyl hydrochloride |
| Company | Square pharmaceuticals plc |
| Also available as |
Indications
- Adjunct in the treatment of all forms of parkinsonism
- Adjuvant therapy when treating Parkinsonism with levodopa
- Control of extrapyramidal disorders
- Useful in the treatment of symptoms associated with Parkinson’s disease
- Control of extrapyramidal reactions to tranquilizers
- Concomitant use with levodopa
- Substitution for other parasympathetic inhibitors
- Use as initial therapy for parkinsonism
- Treatment of drug-induced parkinsonism
Description
- Exerts direct inhibitory effect upon the parasympathetic nervous system
- Relaxing effect on smooth musculature
- Inhibitory effect upon the parasympathetic nervous system
Pharmacology
- Non-selective muscarinic acetylcholine receptor antagonist
- Higher affinity for central muscarinic receptors in the cerebral cortex
- Lower affinity for peripheral muscarinic receptors
- Modification of nicotinic acetylcholine receptor neurotransmission
- Enhanced dopamine release in the striatum
Dosage & Administration
- Individualized dosage
- Low initial dose with gradual increments
- Dosing adjustment based on patient reaction
- Need for atropine in postencephalitic patients
- Administration before or after meals based on patient reaction
- Dose adjustment for concomitant use with levodopa or other parasympathetic inhibitors
- Precautions for abrupt withdrawal of treatment
Interaction
- Additive effects with cannabinoids, barbiturates, opiates, and alcohol
- Increased sedative effects with alcohol or other CNS depressants
- Intensification of anticholinergic effects with monoamine oxidase inhibitors and tricyclic antidepressants
- Increased risk for tardive dyskinesia
- Need for dose reduction during concomitant therapy with other medications
Contraindications
- Hypersensitivity to Trihexyphenidyl
- Narrow angle glaucoma
Side Effects
- Dryness of the mouth
- Blurred vision
- Dizziness
- Nausea
- Nervousness
- Suppurative parotitis
- Skin rashes
- Dilatation of the colon
- Paralytic ileus
- Psychiatric manifestations such as delusions and hallucinations
- Cognitive dysfunctions
- Constipation
- Drowsiness
- Urinary hesitancy or retention
- Tachycardia
- Dilation of the pupil
- Increased intraocular pressure
- Choreiform movements
- Weakness
- Vomiting
- Headache
- Exacerbation of parkinsonism with abrupt withdrawal
Pregnancy & Lactation
- Use during pregnancy when need outweighs risk
- Caution in nursing women
- Potential suppression of lactation
Precautions & Warnings
- Gonioscope evaluation prior to therapy
- Monitoring of intraocular pressures
- Caution in hot weather and with atropine-like drugs
- Consideration of narrow angle glaucoma in case of blurred vision
- Anhidrosis and hyperthermia precautions
- Potential risk of Neuroleptic Malignant Syndrome
Overdose Effects
- Central symptoms of atropine intoxication
- Dilated and sluggish pupils
- Warm, dry skin
- Facial flushing
- Decreased secretions
- Elevated temperature
- Tachycardia and cardiac arrhythmias
- Neuropsychiatric signs
- Stupor, coma, paralysis, cardiac and respiratory arrest
Therapeutic Class
- Antiparkinson drugs
Storage Conditions
- Store at temperature not exceeding 30°C
- Protect from light