Tridyl 5 mg/5 ml (Syrup)
50 ml bottle: ৳ 125.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Trihexyphenidyl hydrochloride |
| Company | Square pharmaceuticals plc |
| Also available as |
Indications
- Adjunct in the treatment of parkinsonism
- Adjuvant therapy with levodopa
- Control of extrapyramidal disorders
Description
- Exerts direct inhibitory effect on parasympathetic nervous system
- Relaxing effect on smooth musculature
Pharmacology
- Non-selective muscarinic acetylcholine receptor antagonist
- Higher affinity for central muscarinic receptors in cerebral cortex
- Lower affinity for peripherally located receptors
- May modify nicotinic acetylcholine receptor neurotransmission
- Enhanced dopamine release in striatum
Dosage & Administration
- Individualized dosage
- Low initial dose for patients over 60 years
- Gradual dose increase
- Optimal dosage for different forms of parkinsonism
- Initiation and adjustment with tranquilizers
- Concomitant use with levodopa and other parasympathetic inhibitors
- Dosing time optimization
- Safety and effectiveness in pediatric patients not established
Interaction
- Additive effects with cannabinoids, barbiturates, opiates, and alcohol
- Increased sedative effects with CNS depressants
- Intensification of anticholinergic effects with MAO inhibitors and tricyclic antidepressants
- Increased risk for tardive dyskinesia
- Necessity of dose reduction with concurrent use of other medications
Contraindications
- Hypersensitivity to Trihexyphenidyl
- Narrow angle glaucoma
Side Effects
- Dryness of the mouth
- Blurred vision
- Dizziness
- Nausea
- Nervousness
- Suppurative parotitis
- Skin rashes
- Dilatation of the colon
- Paralytic ileus
- Psychiatric manifestations
- Cognitive dysfunctions
- Constipation
- Drowsiness
- Urinary hesitancy or retention
- Tachycardia
- Dilation of the pupil
- Increased intraocular pressure
- Choreiform movements
- Weakness
- Vomiting
- Headache
- Exacerbation of parkinsonism with abrupt treatment withdrawal
- Neuroleptic malignant syndrome
- Angle-closure glaucoma
- Paradoxical sinus bradycardia
- Dry skin
- Cycloplegia
- Adverse events in pediatric patients
Pregnancy & Lactation
- Caution in use during pregnancy
- Potential suppression of lactation
- Benefit outweighing potential risk in nursing women
Precautions & Warnings
- Gonioscope evaluation prior to initiation of therapy
- Monitoring of intraocular pressures
- Consideration of narrow angle glaucoma with blurring of vision
- Administration caution in hot weather and with other atropine-like drugs
- Potential occurrence of anhidrosis and hyperthermia
- Risk of Neuroleptic Malignant Syndrome
Overdose Effects
- Typical central symptoms of atropine intoxication
- Peripheral signs of parasympathetic blockade
- Neuropsychiatric signs
- Stupor, coma, paralysis, cardiac and respiratory arrest, death
- Symptomatic and supportive therapy
- Limitation of absorption
- Gastric lavage
- Administration of diazepam or short-acting barbiturate
- Contraindication of phenothiazines
- Respiratory support
- Fluid volume replacement
- Maintenance of acid-balance
- Necessity of urinary catheterization
- Unknown dialyzability
Therapeutic Class
- Antiparkinson drugs
Storage Conditions
- Store at temperature not exceeding 30°C
- Dry place
- Protection from light