Diretic-DS 40 mg+50 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Furosemide spironolactone |
| Company | Drug international ltd |
| Also available as |
Indications
- Essential hypertension
- Chronic congestive heart failure
- Hepatic cirrhosis
- Swelling due to excess fluid retention
- Hyperaldosteronism
Mode of Action
Furosemide inhibits the Na+/K+/2Cl- co-transporter in the ascending Loop of Henle and blocks the reabsorption of sodium, potassium, and chloride ions; spironolactone inhibits the reabsorption of sodium in exchange for potassium at the distal tubule by antagonizing the action of aldosterone.
Dosage and Administration
- 1 to 4 tablets daily (20 to 80 mg of Furosemide and 50 to 200 mg of spironolactone) according to the patient’s response
- For stabilized patients requiring a higher dosage, one to two tablets daily (Furosemide 40 to 80 mg and spironolactone 50 to 100 mg)
- Not suitable for use in children
- May be excreted more slowly in the elderly
Interaction
Increased risk of hyperkalemia with ACE inhibitors or potassium salts; increased levels of cardiac glycosides with digoxin; corticosteroids may cause hypokalemia if used with spironolactone; blood pressure lowering and diuretic effects may be reduced when used with indomethacin and possibly other non-steroidal anti-inflammatory drugs.
Contraindications
- Anuria
- Acute renal insufficiency
- Severe impairment of renal function
- Hyperkalaemia
- Addison's disease
- Hypersensitivity to spironolactone, Furosemide, or sulphonamides
Side Effects
- Headache
- Drowsiness
- Gastrointestinal distress
- Ataxia
- Mental confusion
- Skin rashes
- Gynaecomastia
- Breast enlargement
- Hirsutism
- Deepening of the voice
- Menstrual irregularities
- Impotence
- Transient increase in blood-urea-nitrogen concentrations
- Mild acidosis
- Hyponatremia
- Excessive diuresis
- Dehydration
- Reduction in blood volume
- Circulatory collapse
- Potassium and magnesium depletion
- Cardiac arrhythmias
Pregnancy and Lactation
Spironolactone may cross the placental barrier; Furosemide may cause fetal abnormalities; alternative method of infant feeding should be instituted if use of spironolactone is essential; breast-feeding should be discontinued if treatment with Furosemide is essential.
Precautions and Warnings
Caution should be taken in patients liable to electrolyte deficiency, diabetes, enlarged prostate, hypotension, and hypovolemia
Therapeutic Class
- Potassium-sparing diuretics
- Aldosterone antagonists
Storage Conditions
Keep below 30°C temperature, away from light and moisture. Keep out of the reach of children.