Docefrez 20 mg/vial (IV Infusion)
Medicine Details
| Category | Details |
|---|---|
| Generic | Docetaxel trihydrate |
| Company | Healthcare pharmaceuticals ltd |
| Also available as |
Indications
- Breast Cancer for locally advanced or metastatic BC after chemotherapy failure
- Adjuvant treatment of operable node-positive BC
- Non-small Cell Lung Cancer for locally advanced or metastatic NSCLC after platinum therapy failure
- with cisplatin for unresectable, locally advanced or metastatic untreated NSCLC
- Castration-Resistant Prostate Cancer with prednisone
- Gastric Adenocarcinoma with cisplatin and fluorouracil for untreated advanced GC
- Squamous Cell Carcinoma of the Head and Neck with cisplatin and fluorouracil for induction treatment
Pharmacology
Acts by disrupting the microtubular network in cells essential for vital mitotic and interphase cellular functions. Promotes assembly of tubulin into stable microtubules while inhibiting their disassembly. Binds to free tubulin, decreasing intracellular concentration of tubulin. Found to be cytotoxic against various tumor cell lines.
Dosage & Administration
- Administered intravenously over 1 hr every 3 weeks
- Dosage varies for different cancer types
- Premedication with oral corticosteroids
- Requires facility equipped to manage possible complications like anaphylaxis
- Use only a 21 gauge needle to withdraw
Interaction
CYP3A4 substrate, metabolism may be modified by concomitant administration of compounds that induce, inhibit, or are metabolized by CYP3A4
Contraindications
- Neutrophil counts of <1500 cells/mm^3
- History of severe hypersensitivity reactions to docetaxel or drugs formulated with polysorbate 80
Side Effects
- Infections
- Neutropenia
- Anemia
- Febrile neutropenia
- Hypersensitivity
- Thrombocytopenia
- Neuropathy
- Dysgeusia
- Dyspnea
- Constipation
- Anorexia
- Nail disorders
- Fluid retention
- Asthenia
- Pain
- Nausea
- Diarrhea
- Vomiting
- Mucositis
- Alopecia
- Skin reactions
- Myalgia
Pregnancy & Lactation
Can cause fetal harm when administered to a pregnant woman. No information regarding presence in human milk or effects on milk production or the breastfed child
Precautions & Warnings
- Administered under supervision of a physician experienced in the use of antineoplastic agents
- Higher risk of severe adverse reactions in patients with hepatic impairment
- Do not administer to patients with neutrophil counts of less than 1,500 cells/mm^3
- Monitoring for severe hypersensitivity reactions
- Possible treatment-related acute myeloid leukemia
Overdose Effects
No known antidote for docetaxel overdose. Close monitoring of vital functions. Expected complications include bone marrow suppression, peripheral neurotoxicity, and mucositis. Administration of therapeutic G-CSF recommended.
Therapeutic Class
Cytotoxic Chemotherapy
Storage Conditions
Store between 2°C and 25°C, protected from light. Freezing does not adversely affect the product.