Docefrez 20 mg/vial (IV Infusion)

20 mg vial: ৳ 4,000.00

Medicine Details

Category	Details
Generic	Docetaxel trihydrate
Company	Healthcare pharmaceuticals ltd
Also available as	Docefrez 80 mg injection

Indications

Breast Cancer for locally advanced or metastatic BC after chemotherapy failure
Adjuvant treatment of operable node-positive BC
Non-small Cell Lung Cancer for locally advanced or metastatic NSCLC after platinum therapy failure
with cisplatin for unresectable, locally advanced or metastatic untreated NSCLC
Castration-Resistant Prostate Cancer with prednisone
Gastric Adenocarcinoma with cisplatin and fluorouracil for untreated advanced GC
Squamous Cell Carcinoma of the Head and Neck with cisplatin and fluorouracil for induction treatment

Pharmacology

Acts by disrupting the microtubular network in cells essential for vital mitotic and interphase cellular functions. Promotes assembly of tubulin into stable microtubules while inhibiting their disassembly. Binds to free tubulin, decreasing intracellular concentration of tubulin. Found to be cytotoxic against various tumor cell lines.

Dosage & Administration

Administered intravenously over 1 hr every 3 weeks
Dosage varies for different cancer types
Premedication with oral corticosteroids
Requires facility equipped to manage possible complications like anaphylaxis
Use only a 21 gauge needle to withdraw

Interaction

CYP3A4 substrate, metabolism may be modified by concomitant administration of compounds that induce, inhibit, or are metabolized by CYP3A4

Contraindications

Neutrophil counts of <1500 cells/mm^3
History of severe hypersensitivity reactions to docetaxel or drugs formulated with polysorbate 80

Side Effects

Infections
Neutropenia
Anemia
Febrile neutropenia
Hypersensitivity
Thrombocytopenia
Neuropathy
Dysgeusia
Dyspnea
Constipation
Anorexia
Nail disorders
Fluid retention
Asthenia
Pain
Nausea
Diarrhea
Vomiting
Mucositis
Alopecia
Skin reactions
Myalgia

Pregnancy & Lactation

Can cause fetal harm when administered to a pregnant woman. No information regarding presence in human milk or effects on milk production or the breastfed child

Precautions & Warnings

Administered under supervision of a physician experienced in the use of antineoplastic agents
Higher risk of severe adverse reactions in patients with hepatic impairment
Do not administer to patients with neutrophil counts of less than 1,500 cells/mm^3
Monitoring for severe hypersensitivity reactions
Possible treatment-related acute myeloid leukemia

Overdose Effects

No known antidote for docetaxel overdose. Close monitoring of vital functions. Expected complications include bone marrow suppression, peripheral neurotoxicity, and mucositis. Administration of therapeutic G-CSF recommended.

Therapeutic Class

Cytotoxic Chemotherapy

Storage Conditions

Store between 2°C and 25°C, protected from light. Freezing does not adversely affect the product.