Docefrez 80 mg/vial (IV Infusion)
80 mg vial: ৳ 12,688.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Docetaxel trihydrate |
| Company | Healthcare pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of Breast Cancer (BC)
- Treatment of Non-small Cell Lung Cancer (NSCLC)
- Treatment of Castration-Resistant Prostate Cancer (CRPC)
- Treatment of Gastric Adenocarcinoma (GC)
- Treatment of Squamous Cell Carcinoma of the Head and Neck (SCCHN)
Pharmacology
- Antineoplastic agent disrupting microtubular network in cells
- Promotes assembly of tubulin into stable microtubules
- Inhibits microtubule disassembly
- Binds to free tubulin, decreasing critical intracellular concentration of tubulin
- Cytotoxic against various tumor cell lines
Dosage & Administration
- Administered intravenously (IV) over 1 hr every 3 weeks
- Various dosage regimens for different indications
- Premedication with oral corticosteroids recommended
- Adjust dose as needed
Interaction
- CYP3A4 substrate
- Metabolism of docetaxel may be modified by concomitant administration of certain compounds
Contraindications
- Neutrophil counts of <1500 cells/mm3
- History of severe hypersensitivity reactions to docetaxel or polysorbate 80
Side Effects
- Infections
- Neutropenia
- Anemia
- Hypersensitivity
- Thrombocytopenia
- Neuropathy
- Dysgeusia
- Pain
- Nausea
- Vomiting
- Alopecia
- Skin reactions
- Myalgia
- Incidence varies depending on the indication
Pregnancy & Lactation
- Can cause fetal harm when administered to pregnant women
- No information on presence in human milk or effects on breastfeeding
Precautions & Warnings
- Administered under supervision of experienced physician
- Higher risk of severe adverse reactions in patients with hepatic impairment
- Avoid in patients with low neutrophil counts
- Monitoring for severe hypersensitivity reactions and acute myeloid leukemia
Overdose Effects
- No known antidote for docetaxel overdose
- Complications may include bone marrow suppression, peripheral neurotoxicity, and mucositis
- Supportive measures and therapeutic G-CSF recommended in case of overdose
Therapeutic Class
- Cytotoxic Chemotherapy
Storage Conditions
- Store between 2°C and 25°C
- Protected from light
- Freezing does not adversely affect the product