Docefrez 80 mg/vial (IV Infusion)

80 mg vial: ৳ 12,688.00

Medicine Details

Category Details
Generic Docetaxel trihydrate
Company Healthcare pharmaceuticals ltd
Also available as
Docefrez 20 mg injection

Indications

  • Treatment of Breast Cancer (BC)
  • Treatment of Non-small Cell Lung Cancer (NSCLC)
  • Treatment of Castration-Resistant Prostate Cancer (CRPC)
  • Treatment of Gastric Adenocarcinoma (GC)
  • Treatment of Squamous Cell Carcinoma of the Head and Neck (SCCHN)

Pharmacology

  • Antineoplastic agent disrupting microtubular network in cells
  • Promotes assembly of tubulin into stable microtubules
  • Inhibits microtubule disassembly
  • Binds to free tubulin, decreasing critical intracellular concentration of tubulin
  • Cytotoxic against various tumor cell lines

Dosage & Administration

  • Administered intravenously (IV) over 1 hr every 3 weeks
  • Various dosage regimens for different indications
  • Premedication with oral corticosteroids recommended
  • Adjust dose as needed

Interaction

  • CYP3A4 substrate
  • Metabolism of docetaxel may be modified by concomitant administration of certain compounds

Contraindications

  • Neutrophil counts of <1500 cells/mm3
  • History of severe hypersensitivity reactions to docetaxel or polysorbate 80

Side Effects

  • Infections
  • Neutropenia
  • Anemia
  • Hypersensitivity
  • Thrombocytopenia
  • Neuropathy
  • Dysgeusia
  • Pain
  • Nausea
  • Vomiting
  • Alopecia
  • Skin reactions
  • Myalgia
  • Incidence varies depending on the indication

Pregnancy & Lactation

  • Can cause fetal harm when administered to pregnant women
  • No information on presence in human milk or effects on breastfeeding

Precautions & Warnings

  • Administered under supervision of experienced physician
  • Higher risk of severe adverse reactions in patients with hepatic impairment
  • Avoid in patients with low neutrophil counts
  • Monitoring for severe hypersensitivity reactions and acute myeloid leukemia

Overdose Effects

  • No known antidote for docetaxel overdose
  • Complications may include bone marrow suppression, peripheral neurotoxicity, and mucositis
  • Supportive measures and therapeutic G-CSF recommended in case of overdose

Therapeutic Class

  • Cytotoxic Chemotherapy

Storage Conditions

  • Store between 2°C and 25°C
  • Protected from light
  • Freezing does not adversely affect the product

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