Neoclomide 500 mg/vial (IV Infusion)
500 mg vial: ৳ 464.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Cyclophosphamide |
| Company | Healthcare pharmaceuticals ltd |
| Also available as |
Indications
- Malignant lymphomas (Stages III and IV)
- Hodgkin’s disease
- Multiple myeloma
- Leukemias
- Mycosis fungoides
- Neuroblastoma
- Adenocarcinoma of the ovary
- Retinoblastoma
- Carcinoma of the breast
Pharmacology
Cyclophosphamide is biotransformed principally in the liver to active alkylating metabolites by a mixed function microsomal oxidase system. These metabolites interfere with the growth of susceptible rapidly proliferating malignant cells.
Dosage & Administration
- Initial course of 40 to 50 mg/kg
- Intravenous and oral regimens
Interaction
Metabolism and leukopenic activity reportedly increased by chronic administration of high doses of phenobarbital
Contraindications
- Severely depressed bone marrow function
- Previous hypersensitivity to cyclophosphamide
Side Effects
- Nausea and vomiting
- Alopecia
- Leukopenia
- Hemorrhagic ureteritis
- Interstitial pneumonitis
- Fever without documented infection
- Hematologic effects
- Pigmentation of the skin
Pregnancy & Lactation
Pregnancy Category D. Cyclophosphamide is excreted in breast milk.
Precautions & Warnings
- Leukopenia
- Thrombocytopenia
- Tumor cell infiltration of bone marrow
- Impaired hepatic function
- Impaired renal function
Use in Special Populations
- Pediatric use
- Geriatric use
Overdose Effects
No specific antidote
Therapeutic Class
Cytotoxic Chemotherapy
Storage Conditions
Store at a temperature not exceeding 25°C in a dry place