Edeloss Plus 40 mg+50 mg (Tablet)

Unit Price: ৳ 10.00 (5 x 10: ৳ 500.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Furosemide spironolactone
Company Incepta pharmaceuticals ltd
Also available as
Edeloss 20 mg tablet

Title and Categories

  • Edeloss Plus Tablet
  • Hypertension Medication
  • Diuretic and Aldosterone Antagonist

Indications

  • Treatment of essential hypertension
  • Management of chronic congestive heart failure
  • Relief from swelling due to excess fluid retention (edema)
  • Treatment of hepatic cirrhosis with ascites
  • Management of hyperaldosteronism
  • Relief from resistant edema associated with secondary hyperaldosteronism

Pharmacology

  • Combination of Spironolactone (potassium sparing diuretic) and Furosemide (loop diuretic)
  • Complementary mechanisms and sites of action
  • Additive or synergistic diuretic effect
  • Inhibition of Na+/K+/2Cl- co-transporter in ascending Loop of Henle
  • Blockage of reabsorption of sodium, potassium, and chloride ions
  • Increase in urination quantity and sodium excretion
  • Reduction of potassium loss

Dosage and Administration

  • Furosemide 20 and spironolactone 50 mg tablet
  • Furosemide 40 and spironolactone 50 mg tablet
  • Dosage range of 20 to 80 mg of Furosemide and 50 to 200 mg of spironolactone
  • Increased dosage for previously stabilized patients
  • Inappropriate for use in children
  • Slower excretion in the elderly

Interactions

  • Increased risk of hyperkalemia with ACE inhibitors or potassium salts
  • Enhanced levels of cardiac glycosides like digoxin in the blood
  • Potential reduction or abolition of effects when used with indomethacin or other NSAIDs
  • Possible increase in ototoxicity of aminoglycoside antibiotics

Contraindications

  • Anuria
  • Acute renal insufficiency
  • Severe impairment of renal function
  • Hyperkalemia
  • Addison's disease
  • Hypersensitivity to Spironolactone, Furosemide, or sulphonamides

Side Effects

  • Headache, drowsiness, and gastrointestinal distress
  • Ataxia, mental confusion, and skin rashes
  • Gynaecomastia and breast enlargement
  • Endocrine disorders including hirsutism, voice deepening, and impotence
  • Transient increase in blood-urea-nitrogen concentrations and mild acidosis
  • Hyponatremia, hyperkalemia, and dehydration
  • Possible vascular thrombosis and embolism

Pregnancy and Lactation

  • Crossing of spironolactone and its metabolites through placental barrier
  • Animal teratology studies indicating potential fetal abnormalities with Furosemide
  • Use considerations in pregnant women based on benefit versus hazard assessment
  • Detection of Spironolactone and Furosemide metabolites in breast milk
  • Recommendation for alternative method of infant feeding if essential to use Spironolactone
  • Excretion of Furosemide in breast milk and need for discontinuation of breastfeeding if treatment essential

Precautions and Warnings

  • Caution in patients with electrolyte deficiency, diabetes, enlarged prostate, hypotension, and hypovolemia

Therapeutic Class

  • Potassium-sparing diuretics
  • Aldosterone antagonists

Storage Conditions

  • Storage below 30°C temperature
  • Protection from light and moisture
  • Keep out of the reach of children

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