Ascova 100 mg/5 ml (Syrup)

60 ml bottle: ৳ 60.00

Medicine Details

Category Details
Generic Doxophylline
Company Labaid pharma ltd
Also available as
Ascova 200 mg tablet Ascova 400 mg tablet

Indications

  • Bronchial asthma
  • Bronchospasm
  • Chronic obstructive pulmonary disease (COPD)
  • Pulmonary disease with spastic bronchial component

Pharmacology

  • Doxophylline is a novel bronchodilator
  • Structurally differs from Theophylline
  • Selective inhibition of phosphodiesterase 4
  • Relaxes bronchial smooth muscle
  • Decreased affinities toward adenosine A1 and A2 receptors
  • Inhibits platelet activating factor (PAF)
  • Inhibition of leukotriene production

Dosage & Administration

  • Elderly: 200 mg tablet two or three times daily
  • Adults: 400 mg tablet two or three times daily
  • Children >12 years of age: 10 ml syrup or 200 mg tablet two or three times daily
  • Children 6-12 years of age: 6-9 mg/kg body weight two times daily
  • Doxophylline SR tablet to be taken once daily if required daily dose is 400 mg

Interaction

  • Should not be administered with other xanthine preparations
  • Limit consumption of caffeine-containing beverages and food
  • Caution in administering with ephedrine or other sympathomimetic drugs
  • Concurrent administration with erythromycin, TAO, lincomycin, clindamycin, allopurinol, cimetidine, influenza vaccine, propanolol may reduce hepatic clearance
  • Phenytoin, other anticonvulsants, and cigarette smoking may increase clearance

Contraindications

  • Hypersensitivity to the drug or other xanthine derivatives
  • Patients with acute myocardial infarction
  • Patients with hypotension
  • During lactation

Side Effects

  • Nausea
  • Vomiting
  • Epigastric pain
  • Headache
  • Irritability
  • Insomnia
  • Tachycardia
  • Extrasystoles
  • Tachypnea
  • Hyperglycemia
  • Albuminuria
  • Severe cardiac arrhythmias
  • Tonic-clonic seizure

Pregnancy & Lactation

  • The active ingredient does not interfere with pre and postnatal growth in animal tests
  • Use during pregnancy should be evaluated carefully case by case
  • Contraindicated during lactation

Precautions & Warnings

  • Factors that may reduce hepatic clearance
  • Monitoring of blood levels recommended for controlled therapeutic range
  • Caution in administering to patients with cardiac disease, hypertension, elderly, severe hypoxemia, hyperthyroidism, chronic corpulmonale, congestive heart failure, liver disease, peptic ulcer, and renal impairment

Overdose Effects

  • Severe cardiac arrhythmias
  • Tonic-clonic seizure
  • Symptomatic treatment for cardiovascular collapse in case of overdose

Therapeutic Class

  • Bronchodilator
  • Methyl xanthine derivatives

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children
  • To be used only on the prescription of a specialist physician

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