Edemide 40 mg+50 mg (Tablet)

Unit Price: ৳ 10.03 (4 x 10: ৳ 401.20)
Strip Price: ৳ 100.30

Medicine Details

Category Details
Generic Furosemide spironolactone
Company Acme laboratories ltd
Also available as
Edemide 20 mg tablet

Indications

  • Essential hypertension
  • Chronic congestive heart failure
  • Hepatic cirrhosis with ascites
  • Swelling due to excess fluid retention
  • Hyperaldosteronism
  • Resistant edema associated with secondary hyperaldosteronism

Pharmacology

  • Complementary mechanisms of action
  • Additive or synergistic diuretic effect
  • Inhibition of Na+/K+/2Cl- co-transporter
  • Blockage of reabsorption of sodium, potassium, and chloride ions
  • Increased quantity of sodium and water excretion in urine
  • Potassium-sparing diuretic effect

Dosage & Administration

  • Recommended daily dosage range of Furosemide 20 and spironolactone 50 mg
  • Flexibility in dosage for stabilized patients
  • Inappropriateness for use in children
  • Potential slow excretion in the elderly

Interaction

  • Increased risk of hyperkalemia when taken with ACE inhibitors or potassium salts
  • Elevated levels of cardiac glycosides like digoxin
  • Potential digitalis toxicity
  • Possibility of hypokalemia when used with corticosteroids
  • Risk of reduced or abolished diuretic effects when used with certain non-steroidal anti-inflammatory drugs (NSAIDs)
  • Potential increase in ototoxicity of aminoglycoside antibiotics when administered together

Contraindications

  • Anuria
  • Acute renal insufficiency
  • Severe impairment of renal function
  • Hyperkalemia
  • Addison's disease
  • Hypersensitivity to Spironolactone, Furosemide, or sulphonamides

Side Effects

  • Headache and drowsiness
  • Gastrointestinal distress including cramp and diarrhea
  • Ataxia, mental confusion, and skin rashes
  • Gynaecomastia and breast enlargement
  • Endocrine disorders including hirsutism, voice deepening, menstrual irregularities, and impotence
  • Transient increase in blood-urea-nitrogen concentrations
  • Potential hyponatremia and hyperkalemia
  • Dehydration, reduction in blood volume, circulatory collapse, vascular thrombosis, and embolism
  • Serious depletion of potassium and magnesium leading to cardiac arrhythmias

Pregnancy & Lactation

  • Need for careful consideration of benefits vs. hazards in pregnant women
  • Animal teratology studies indicating potential fetal abnormalities with Furosemide
  • Detection of Spironolactone metabolites in breast milk
  • Recommendation for alternative method of infant feeding if essential use of Spironolactone
  • Excretion of Furosemide in breast milk, necessitating discontinuation of breastfeeding if treatment is essential

Precautions & Warnings

  • Caution in patients susceptible to electrolyte deficiency
  • Use with care in diabetes, enlarged prostate, hypotension, and hypovolemia

Therapeutic Class

  • Potassium-sparing diuretics
  • Aldosterone antagonists

Storage Conditions

  • Recommended storage temperature below 30°C
  • Protection from light and moisture
  • Keep out of reach of children

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