Baricit 2 mg (Tablet)
Unit Price: ৳ 20.00 (1 x 10: ৳ 200.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Baricitinib |
| Company | Delta pharma ltd |
| Also available as |
Indications
- Treatment of Rheumatoid Arthritis
- Inadequate response to TNF antagonist therapies
- Moderate to severely active Rheumatoid Arthritis
- Not recommended for use in combination with other JAK inhibitors
- Not recommended for use with biologic DMARDs
- Not recommended for use with potent immunosuppressants
Pharmacology
- Selective inhibitor of Janus kinase JAK1 and JAK2
- Transduction of intracellular signals
- Enzymes involved in haematopoiesis, inflammation and immune function
- Reduction of phosphorylation and activation of STATs
Dosage & Administration
- Recommended dose of 2 mg once daily
- Monotherapy or in combination with Methotrexate or other DMARDS
- Oral administration with or without food
- Not established for pediatric use
- Dose selection in elderly patients with decreased renal function
- No dose adjustment in patients with mild or moderate hepatic impairment
- Not recommended for use in patients with estimated GFR less than 60 mL/min/I .73 m2
Interaction
- Increased exposure when co-administered with strong OAT3 inhibitors
- Not studied in combination with other JAK inhibitors or with biologic DMARDS
Contraindications
- Avoid initiation or interrupt in patients with anemia (Hb < 8 g/dL)
- Avoid initiation or interrupt in patients with lymphopenia (ALC < 500 cells/mm³)
- Avoid initiation or interrupt in patients with neutropenia (ANC < 1000 cells/mm³)
Side Effects
- Most commonly reported ADRs: increased LDL cholesterol, upper respiratory tract infections, nausea
Pregnancy & Lactation
- Contraindicated during pregnancy
- No information on presence in human milk
Precautions & Warnings
- Avoid use in patients with active, serious infection
- Not to be given to patients with active TB
- Consider risks and benefits prior to initiating therapy in patients with known malignancy
- Use with caution in patients at increased risk of thrombosis or gastrointestinal perforation
- To be dispensed only by the prescription of a registered physician
Overdose Effects
- Monitoring for signs and symptoms of adverse reactions
- Appropriate treatment for patients with adverse reactions
Therapeutic Class
- Immunosuppressant
Storage Conditions
- Store at or below 30°C temperature
- Keep away from light and wet place
- Keep out of reach of children