Frusin Plus 40 mg+50 mg (Tablet)

Unit Price: ৳ 8.03 (3 x 10: ৳ 240.90)

Strip Price: ৳ 80.30

Medicine Details

Spironolactone and Furosemide have different but complementary mechanisms and sites of action. When given together, they produce additive or synergistic diuretic effects. Furosemide inhibits the Na+/K+/2Cl- co-transporter in the ascending Loop of Henle and blocks the reabsorption of sodium, potassium, and chloride ions, thereby increasing the quantity of sodium and the volume of water excreted in the urine. Spironolactone inhibits the reabsorption of sodium in exchange for potassium at the distal tubule by antagonizing the action of aldosterone.

Furosemide 20 and spironolactone 50 mg: 1 to 4 tablets daily according to the patient’s response.
Furosemide 40 and spironolactone 50 mg: For previously stabilized patients requiring a higher dosage of spironolactone and Furosemide, This tablet can be used at a dose of one to two tablets daily.

Increased risk of hyperkalemia when taken together with ACE inhibitors or potassium salts.
Spironolactone increases the levels of cardiac glycosides such as digoxin in the blood, resulting in digitalis toxicity.
Corticosteroids may cause hypokalemia when used with Spironolactone.

Contraindicated in patients with anuria, acute renal insufficiency, rapidly deteriorating or severe impairment of renal function, hyperkalemia, Addison's disease, and in patients who are hypersensitive to Spironolactone, Furosemide, or sulphonamides.

Headache and drowsiness
Gastrointestinal distress
Ataxia, mental confusion, and skin rashes
Gynaecomastia and breast enlargement
Hirsutism, deepening of the voice, menstrual irregularities, and impotence
Transient increase in blood-urea-nitrogen concentrations
Mild acidosis
Hyponatremia and hyperkalemia
Excessive diuresis leading to dehydration and reduction in blood volume with circulatory collapse
Serious depletion of potassium and magnesium leading to cardiac arrhythmias.

Spironolactone and its metabolites may cross the placental barrier. The use of spironolactone in pregnant women requires that the anticipated benefit be weighed against the possible hazards to the mother and fetus.
Animal teratology studies indicate that Furosemide may cause fetal abnormalities. Therefore, Furosemide should only be used in women in childbearing age when appropriate contraceptive measures are taken or if the potential benefits justify the potential risks to the fetus.
Metabolites of Spironolactone have been detected in breast milk. If use of Spironolactone is considered essential, an alternative method of infant feeding should be instituted. Furosemide is excreted in breast milk, and breastfeeding should be discontinued if treatment is essential.

Caution should be taken in patients liable to electrolyte deficiency.
Frusin Plus should also be used with caution in diabetes, enlarged prostate, hypotension, and in hypovolemia.