Viagrazen 100 mg (Tablet)
Unit Price: ৳ 45.00 (1 x 6: ৳ 270.00)
Strip Price: ৳ 270.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Sildenafil citrate |
| Company | Zenith pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of erectile dysfunction in men
- Treatment of pulmonary arterial hypertension
Description
- Selective, reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5)
- Causes smooth muscle relaxation and increased blood flow in penile tissues during sexual stimulation
Pharmacology
- Enhances effect of nitric oxide in smooth muscle relaxation
- Rapidly absorbed after oral administration
- Metabolized by hepatic metabolism
- Maximum observed plasma concentrations reached within 30 to 120 minutes of oral dosing in the fasted state
Dosage & Administration
- Recommended starting dose of 50 mg taken 1 hour before sexual activity
- Dose may be increased to 100 mg or decreased to 25 mg based on toleration
- For pulmonary arterial hypertension, the recommended dose is 20 mg three times a day
Interaction
- Metabolism mediated by cytochrome P450 isoforms 3A4 and 2C9
- Inhibitors of these isoenzymes may reduce clearance
- Inducers of these isoenzymes may increase clearance
Contraindications
- Hypersensitivity to any component of the medication
- Use of organic nitrates, either regularly or intermittently
Side Effects
- Body as a whole
- Cardiovascular
- Digestive
- Hemic and Lymphatic
- Metabolic and Nutritional
- Musculoskeletal
- Nervous
- Respiratory
- Skin and Appendages
- Special Senses
- Urogenital
- Serious cardiovascular, cerebrovascular, and vascular events reported post-marketing
Pregnancy & Lactation
- Pregnancy category B
- Not indicated for use by women
- Animal studies show no evidence of teratogenicity or embryotoxicity
Precautions & Warnings
- Evaluation of erectile dysfunction should include determination of potential underlying causes
- Caution advised when PDE5 inhibitors are co-administered with alpha-blockers
- Consideration should be given to patients with bleeding disorders and active peptic ulceration
Overdose Effects
- Adverse events similar to those seen at lower doses
- Standard supportive measures should be adopted in case of overdose
Therapeutic Class
- Drugs for Erectile Dysfunction
Storage Conditions
- Keep in a dry place, away from light and heat
- Keep out of the reach of children