Viagrazen 100 mg (Tablet)

Unit Price: ৳ 45.00 (1 x 6: ৳ 270.00)
Strip Price: ৳ 270.00

Medicine Details

Category Details
Generic Sildenafil citrate
Company Zenith pharmaceuticals ltd
Also available as

Indications

  • Treatment of erectile dysfunction in men
  • Treatment of pulmonary arterial hypertension

Description

  • Selective, reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5)
  • Causes smooth muscle relaxation and increased blood flow in penile tissues during sexual stimulation

Pharmacology

  • Enhances effect of nitric oxide in smooth muscle relaxation
  • Rapidly absorbed after oral administration
  • Metabolized by hepatic metabolism
  • Maximum observed plasma concentrations reached within 30 to 120 minutes of oral dosing in the fasted state

Dosage & Administration

  • Recommended starting dose of 50 mg taken 1 hour before sexual activity
  • Dose may be increased to 100 mg or decreased to 25 mg based on toleration
  • For pulmonary arterial hypertension, the recommended dose is 20 mg three times a day

Interaction

  • Metabolism mediated by cytochrome P450 isoforms 3A4 and 2C9
  • Inhibitors of these isoenzymes may reduce clearance
  • Inducers of these isoenzymes may increase clearance

Contraindications

  • Hypersensitivity to any component of the medication
  • Use of organic nitrates, either regularly or intermittently

Side Effects

  • Body as a whole
  • Cardiovascular
  • Digestive
  • Hemic and Lymphatic
  • Metabolic and Nutritional
  • Musculoskeletal
  • Nervous
  • Respiratory
  • Skin and Appendages
  • Special Senses
  • Urogenital
  • Serious cardiovascular, cerebrovascular, and vascular events reported post-marketing

Pregnancy & Lactation

  • Pregnancy category B
  • Not indicated for use by women
  • Animal studies show no evidence of teratogenicity or embryotoxicity

Precautions & Warnings

  • Evaluation of erectile dysfunction should include determination of potential underlying causes
  • Caution advised when PDE5 inhibitors are co-administered with alpha-blockers
  • Consideration should be given to patients with bleeding disorders and active peptic ulceration

Overdose Effects

  • Adverse events similar to those seen at lower doses
  • Standard supportive measures should be adopted in case of overdose

Therapeutic Class

  • Drugs for Erectile Dysfunction

Storage Conditions

  • Keep in a dry place, away from light and heat
  • Keep out of the reach of children

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