Frusiton 20 mg+50 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Furosemide spironolactone |
| Company | Globe pharmaceuticals ltd |
| Also available as |
Title
- Frusemide and Spironolactone Combination Tablet
Categories
- Medicine
- Pharmaceutical
Description
- This medicine is indicated for essential hypertension, chronic congestive heart failure, hepatic cirrhosis, abdominal cavity fluid collection (ascites), swelling due to excess fluid retention (edema), hyperaldosteronism, and resistant edema associated with secondary hyperaldosteronism. It is a combination of spironolactone (potassium-sparing diuretic) and furosemide (loop diuretic) which have complementary mechanisms of action. The recommended dosage varies based on the patient's response, and caution is advised in certain patient populations such as those with electrolyte deficiency, diabetes, enlarged prostate, hypotension, and hypovolemia. The medicine is contraindicated in patients with specific conditions like anuria, acute renal insufficiency, severe impairment of renal function, hyperkalemia, Addison's disease, and hypersensitivity to spironolactone, furosemide, or sulphonamides. It is also important to be aware of potential drug interactions, side effects, and precautions during pregnancy and lactation.
Dimensions
6mm x 6mm x 3mm
Color Options
- White
- Pink
Ingredients
- Spironolactone
- Furosemide
- Potassium
- Sulphonamides
Dosage and Administration
- Furosemide 20 mg and spironolactone 50 mg: 1 to 4 tablets daily (20 to 80 mg of furosemide and 50 to 200 mg of spironolactone) according to the patient's response.
- Furosemide 40 mg and spironolactone 50 mg: For previously stabilized patients requiring a higher dosage, this tablet can be used at a dose of one to two tablets daily (Furosemide 40 to 80 mg and spironolactone 50 to 100 mg).
- Not suitable for use in children. May be excreted more slowly in the elderly.
Pharmacology
Spironolactone and furosemide have different but complementary mechanisms and sites of action, producing additive or synergistic diuretic effects. Furosemide inhibits the Na+/K+/2Cl- co-transporter in the ascending Loop of Henle, blocking the reabsorption of sodium, potassium, and chloride ions. Spironolactone inhibits the reabsorption of sodium in exchange for potassium at the distal tubule by antagonizing the action of aldosterone, favoring sodium excretion and reducing the excess loss of potassium induced by furosemide.
Interaction
- Increased risk of hyperkalemia when taken with ACE inhibitors or potassium salts
- Elevated levels of cardiac glycosides such as digoxin when combined with spironolactone
- Potential reduction or abolition of blood pressure lowering and diuretic effects when used together with indomethacin and possibly other non-steroidal anti-inflammatory drugs (NSAIDs)
- Increased ototoxicity of aminoglycoside antibiotics when administered with furosemide
Contraindications
Anuria, acute renal insufficiency, severe impairment of renal function, hyperkalemia, Addison's disease, and hypersensitivity to spironolactone, furosemide, or sulphonamides
Side Effects
- Headache and drowsiness
- Gastrointestinal distress including cramping and diarrhea
- Ataxia and mental confusion
- Gynaecomastia and breast enlargement
- Endocrine disorders such as hirsutism, voice deepening, menstrual irregularities, and impotence
- Transient increase in blood-urea-nitrogen concentrations and mild acidosis
- Hyponatremia, hyperkalemia, dehydration, reduction in blood volume with circulatory collapse, vascular thrombosis, and embolism, particularly in elderly patients
- Serious depletion of potassium and magnesium leading to cardiac arrhythmias
Pregnancy and Lactation
- Spironolactone and its metabolites may cross the placental barrier, and the anticipated benefit must be weighed against possible hazards to the mother and fetus during pregnancy
- Furosemide may cause fetal abnormalities, and its use in women of childbearing age should consider potential risks to the fetus
- Metabolites of spironolactone and furosemide have been detected in breast milk, and alternative methods of infant feeding should be considered during lactation
Precautions and Warnings
Caution should be exercised in patients prone to electrolyte deficiency, diabetes, enlarged prostate, hypotension, and hypovolemia.
Therapeutic Class
Potassium-sparing diuretics & Aldosterone antagonists
Storage Conditions
Keep below 30°C temperature, away from light and moisture, and out of the reach of children