Carceva Plus 75 mg+75 mg (Tablet)

Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00

Medicine Details

Category Details
Generic Clopidogrel aspirin
Company Nipro jmi pharma ltd

Indications

  • Reduction of Myocardial Infarction (MI)
  • Reduction of Stroke
  • Treatment of non-ST-segment elevation ACS
  • Treatment of ST-segment elevation ACS
  • Reduction of rate of MI and Stroke in patients with ACS
  • Reduction of rate of MI and Stroke in patients with Peripheral Arterial Disease

Pharmacology

  • Inhibition of platelet activation
  • Inhibition of platelet aggregation
  • Dose-dependent inhibition of platelet aggregation
  • Irreversible binding of active metabolite to P2Y12 receptors
  • Inhibition of platelet cyclooxygenase
  • Inhibition of thromboxane A2 generation
  • Plasma concentrations of parent compound below quantification limit
  • Extensive metabolism by the liver
  • Excretion in urine and faeces
  • 8-hour elimination half-life
  • Rapid absorption after oral administration
  • Peak plasma levels reached approximately 1 hour after dosing
  • Linear pharmacokinetics in specific dose range

Dosage & Administration

  • Recommended dose of 75 mg once daily
  • Initiation with a single 300 mg loading dose for acute coronary syndrome patients
  • Continuation of Aspirin in combination with Clopidogrel
  • No dosage adjustment for elderly patients
  • No dosage adjustment for patients with renal impairment

Interaction

  • No modification of Clopidogrel-mediated inhibition by Aspirin
  • Potentiation of aspirin effect on platelet aggregation by Clopidogrel
  • No modification of heparin dose by Clopidogrel
  • No effect of heparin on inhibition of platelet aggregation by Clopidogrel
  • Increased occult gastrointestinal blood loss with NSAIDs
  • Co-administration caution with NSAIDs
  • Caution in co-administration with Warfarin

Contraindications

  • Hypersensitivity to the drug substance or any component
  • Active pathological bleeding

Side Effects

  • Generally well-tolerated

Pregnancy & Lactation

  • Use during first and second trimesters if clearly needed
  • Contraindicated during third trimester
  • Unknown excretion in human breast milk
  • Excretion of Aspirin in human milk
  • Discontinuation during breastfeeding

Precautions & Warnings

  • Prolongs bleeding time
  • Rare reports of Thrombotic thrombocytopenic purpura (TTP)
  • Possible development of Reye's syndrome
  • Hypersensitivity reactions

Use in Special Populations

  • Not recommended for children under 12 years
  • Caution in children due to potential contribution to Reye’s syndrome by Aspirin

Overdose Effects

  • Potential bleeding complications in Clopidogrel overdose
  • Symptoms of moderate Aspirin intoxication
  • Symptoms of severe Aspirin intoxication
  • Treatment with platelet transfusion for Clopidogrel overdose
  • Treatment by inducing vomiting and gastric lavage for Aspirin intoxication
  • Haemodialysis and symptomatic treatment for severe Aspirin intoxication

Therapeutic Class

  • Anti-platelet drugs

Storage Conditions

  • Keep in cool & dry place (below 30°C)
  • Protected from light & moisture
  • Keep out of the reach of children

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