Carceva Plus 75 mg+75 mg (Tablet)
Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clopidogrel aspirin |
| Company | Nipro jmi pharma ltd |
Indications
- Reduction of Myocardial Infarction (MI)
- Reduction of Stroke
- Treatment of non-ST-segment elevation ACS
- Treatment of ST-segment elevation ACS
- Reduction of rate of MI and Stroke in patients with ACS
- Reduction of rate of MI and Stroke in patients with Peripheral Arterial Disease
Pharmacology
- Inhibition of platelet activation
- Inhibition of platelet aggregation
- Dose-dependent inhibition of platelet aggregation
- Irreversible binding of active metabolite to P2Y12 receptors
- Inhibition of platelet cyclooxygenase
- Inhibition of thromboxane A2 generation
- Plasma concentrations of parent compound below quantification limit
- Extensive metabolism by the liver
- Excretion in urine and faeces
- 8-hour elimination half-life
- Rapid absorption after oral administration
- Peak plasma levels reached approximately 1 hour after dosing
- Linear pharmacokinetics in specific dose range
Dosage & Administration
- Recommended dose of 75 mg once daily
- Initiation with a single 300 mg loading dose for acute coronary syndrome patients
- Continuation of Aspirin in combination with Clopidogrel
- No dosage adjustment for elderly patients
- No dosage adjustment for patients with renal impairment
Interaction
- No modification of Clopidogrel-mediated inhibition by Aspirin
- Potentiation of aspirin effect on platelet aggregation by Clopidogrel
- No modification of heparin dose by Clopidogrel
- No effect of heparin on inhibition of platelet aggregation by Clopidogrel
- Increased occult gastrointestinal blood loss with NSAIDs
- Co-administration caution with NSAIDs
- Caution in co-administration with Warfarin
Contraindications
- Hypersensitivity to the drug substance or any component
- Active pathological bleeding
Side Effects
- Generally well-tolerated
Pregnancy & Lactation
- Use during first and second trimesters if clearly needed
- Contraindicated during third trimester
- Unknown excretion in human breast milk
- Excretion of Aspirin in human milk
- Discontinuation during breastfeeding
Precautions & Warnings
- Prolongs bleeding time
- Rare reports of Thrombotic thrombocytopenic purpura (TTP)
- Possible development of Reye's syndrome
- Hypersensitivity reactions
Use in Special Populations
- Not recommended for children under 12 years
- Caution in children due to potential contribution to Reye’s syndrome by Aspirin
Overdose Effects
- Potential bleeding complications in Clopidogrel overdose
- Symptoms of moderate Aspirin intoxication
- Symptoms of severe Aspirin intoxication
- Treatment with platelet transfusion for Clopidogrel overdose
- Treatment by inducing vomiting and gastric lavage for Aspirin intoxication
- Haemodialysis and symptomatic treatment for severe Aspirin intoxication
Therapeutic Class
- Anti-platelet drugs
Storage Conditions
- Keep in cool & dry place (below 30°C)
- Protected from light & moisture
- Keep out of the reach of children