Dominaaf 5 mg/5 ml (Oral Suspension)

60 ml bottle: ৳ 35.00

Medicine Details

Category Details
Generic Domperidone maleate
Company Naafco pharma ltd
Also available as
Dominaaf 10 mg tablet

Title

Dominaaf 5 mg/5 ml Suspension

Categories

  • Medicine
  • Pharmaceutical

Indications

  • Dyspeptic symptom complex
  • Delayed gastric emptying
  • Gastroesophageal reflux
  • Esophagitis
  • Acute nausea and vomiting
  • Parkinson's disease
  • Radiological studies

Pharmacology

Dopamine antagonist, Gastroprokinetic action by blocking dopamine receptors in the Chemoreceptor Trigger Zone (CTZ) and stomach. Restores normal motility and tone of the upper gastrointestinal tract, enhances antral and duodenal peristalsis, regulates contraction of the pylorus, increases esophageal peristalsis and lower esophageal sphincter pressure, facilitates gastric emptying.

Dosage & Administration

  • Adults:
    • 10-20 mg, every 6-8 hours daily
    • Maximum dose of 80 mg daily
  • Children:
    • 2-4 ml suspension/10 kg body weight, every 6-8 hours daily

Interaction

  • Anticholinergic drugs may antagonize the effect
  • Concurrent use with drugs that significantly inhibit CYP3A4 may increase plasma levels

Contraindications

  • Hypersensitivity to domperidone
  • Neonates
  • Gastrointestinal hemorrhage
  • Mechanical obstruction or perforation
  • Prolactin releasing pituitary tumor (prolactinoma)

Side Effects

  • Transient intestinal cramps
  • Rare extrapyramidal phenomena
  • Increase in plasma prolactin level
  • Rare allergic reactions such as rash and urticaria

Pregnancy & Lactation

  • Use during the first trimester if justified by therapeutic benefit
  • Excreted in breast milk, caution advised for nursing mothers

Precautions & Warnings

  • Use with caution in children due to risk of extra-pyramidal reactions
  • Use with caution in patients with hepatic impairment

Use in Special Populations

  • Use in infants only with great caution and close medical supervision
  • Use with caution in patients with liver or kidney disorders

Overdose Effects

  • Drowsiness
  • Disorientation
  • Extrapyramidal reactions

Therapeutic Class

Motility Stimulants, Motility stimulants/Dopamine antagonist, Prokinetic drugs

Storage Conditions

Store below 30°C, Protected from light & moisture, Keep out of children's reach

Chemical Structure

  • Molecular Formula: C22H24ClN5O2

Common Questions

  • Used to treat nausea and vomiting
  • Should be taken before meals as per doctor's prescription
  • May cause dizziness and sleepiness

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