Fruspa 20 mg+50 mg (Tablet)
Unit Price: ৳ 6.00 (3 x 10: ৳ 180.00)
Strip Price: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Furosemide spironolactone |
| Company | Zenith pharmaceuticals ltd |
Indications
- Essential hypertension
- Chronic congestive heart failure
- Hepatic cirrhosis with fluid collection in the abdominal cavity (ascites)
- Swelling due to excess fluid retention (edema)
- Hyperaldosteronism
- Resistant edema associated with secondary hyperaldosteronism
Pharmacology
- Spironolactone and Furosemide have complementary mechanisms and sites of action
- Additive or synergistic diuretic effect when given together
- Furosemide inhibits the Na+/K+/2Cl- co-transporter in the ascending Loop of Henle
- Blocks reabsorption of sodium, potassium, and chloride ions
- Spironolactone inhibits the reabsorption of sodium exchange for potassium at the distal tubule
Dosage & Administration
- Furosemide 20mg and spironolactone 50mg: 1-4 tablets daily
- Furosemide 40mg and spironolactone 50mg: 1-2 tablets daily
- Dosage may vary according to patient's response
Interaction
- Increased risk of hyperkalemia when taken with ACE inhibitors or potassium salts
- Increases levels of cardiac glycosides in the blood when taken with digoxin
- Possible reduction in blood pressure lowering and diuretic effects when used with indomethacin or other NSAIDs
Contraindications
- Anuria
- Acute renal insufficiency
- Severe impairment of renal function (creatinine clearance <30 ml/min)
- Hyperkalaemia
- Addison's disease
- Hypersensitivity to Spironolactone, Furosemide, or sulphonamides
Side Effects
- Headache, drowsiness, gastrointestinal distress, cramp, diarrhea
- Ataxia, mental confusion, skin rashes
- Gynaecomastia, breast enlargement, hirsutism, voice deepening, menstrual irregularities, impotence
- Transient increase in blood-urea-nitrogen concentrations, mild acidosis
- Hyponatremia, hyperkalemia, dehydration, reduction in blood volume, circulatory collapse, vascular thrombosis, embolism
- Serious depletion of potassium and magnesium, cardiac arrhythmias
Pregnancy & Lactation
- Spironolactone and its metabolites may cross the placental barrier
- Furosemide may cause fetal abnormalities
- Need for risk-benefit assessment in pregnant women
- Metabolites of Spironolactone detected in breast milk
- Furosemide excreted in breast milk
Precautions & Warnings
- Caution in patients liable to electrolyte deficiency
- Use with caution in diabetes, enlarged prostate, hypotension, hypovolemia
Therapeutic Class
- Potassium-sparing diuretics
- Aldosterone antagonists
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of the reach of children