Rabenaaf 20 mg (Capsule (Enteric Coated))

Unit Price: ৳ 8.00 (6 x 10: ৳ 480.00)
Strip Price: ৳ 80.00

Medicine Details

Category Details
Generic Rabeprazole sodium
Company Naafco pharma ltd

Indications

  • Active duodenal ulcers
  • Active benign gastric ulcers
  • GERD
  • Zollinger-Ellison Syndrome
  • H. pylori eradication

Pharmacology

Rabeprazole suppresses gastric acid secretion by inhibiting the gastric H+/K+-ATPase at the secretory surface of the gastric parietal cell.

Dosage

  • 20mg once daily for active duodenal ulcer and active benign gastric ulcer
  • 20mg once daily for 4-8 weeks for GERD
  • 10mg or 20mg once daily for GERD maintenance
  • 60mg to 120mg once daily for Zollinger-Ellison Syndrome

Administration

Should be taken in the morning before eating, should not be chewed or crushed, but swallowed whole.

Interaction

Potential interaction with ketoconazole, itraconazole, and atazanavir. No interaction with liquid antacids observed.

Contraindications

  • Hypersensitivity to the active substance or excipients
  • Contra-indicated in pregnancy and during breastfeeding.

Side Effects

  • Headache
  • Diarrhoea
  • Abdominal pain
  • Vomiting
  • Constipation
  • Dry mouth
  • Muscle pain
  • Drowsiness
  • Dizziness

Pregnancy & Lactation

US FDA pregnancy category 'C'. No adequate and well-controlled studies in pregnant women. Rabeprazole is likely excreted in human milk.

Precautions & Warnings

  • Malignancy should be excluded prior to commencing treatment
  • Long-term treatment may increase risk of hip, wrist and spine fracture
  • Hypomagnesaemia
  • Interference with laboratory tests
  • Influence on vitamin B12 absorption
  • Subacute cutaneous lupus erythematosus (SCLE)
  • Patients with hepatic impairment need caution
  • Co-administration with atazanavir not recommended
  • Possible increased risk of gastrointestinal infections

Use in Special Populations

  • No dosage adjustment necessary for renal or hepatic impairment
  • Not recommended for use in children

Overdose Effects

Effects generally minimal, reversible without further medical intervention. No specific antidote known. Not dialysable.

Therapeutic Class

Proton Pump Inhibitor

Storage Conditions

Keep below 30°C, away from light & moisture, keep out of the reach of children.

Chemical Structure

  • Molecular Formula: C18H21N3O3S
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-942-rabeprazole-sodium-chemical-structure-atwg0Q4PlndQZhOY9GHX.svg

Common Questions

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