Furo Plus 20 mg+50 mg (Tablet)
Unit Price: ৳ 6.02 (3 x 10: ৳ 180.60)
Strip Price: ৳ 60.20
Medicine Details
| Category | Details |
|---|---|
| Generic | Furosemide spironolactone |
| Company | Beacon pharmaceuticals plc |
Indications
- Essential hypertension
- Chronic congestive heart failure
- Hepatic cirrhosis with ascites
- Swelling due to excess fluid retention (edema)
- Hyperaldosteronism
- Resistant edema associated with secondary hyperaldosteronism
Pharmacology
- Potassium-sparing diuretic
- Loop diuretic
- Complementary mechanisms and sites of action
- Additive or synergistic diuretic effect
- Inhibits Na+/K+/2Cl- co-transporter
- Blocks reabsorption of sodium, potassium, and chloride ions
- Induces potassium loss
- Inhibits reabsorption of sodium in exchange for potassium at the distal tubule
- Antagonizes the action of aldosterone
Dosage & Administration
- Furosemide 20 and spironolactone 50 mg: 1 to 4 tablets daily
- Furosemide 40 and spironolactone 50 mg: One to two tablets daily
- Use in children not recommended
- Elderly patients may excrete the drugs more slowly
Interaction
- Increased risk of hyperkalemia with ACE inhibitors or potassium salts
- Elevated levels of cardiac glycosides such as digoxin in the blood
- Reduced or abolished blood pressure lowering and diuretic effects when used with indomethacin
- Increased ototoxicity of aminoglycoside antibiotics when used with Furosemide
- Reduced natriuretic and anti-hypertensive effect of Furosemide when used with sucralfate
Contraindications
- Anuria
- Acute renal insufficiency
- Severe impairment of renal function (creatinine clearance <30 ml/min)
- Hyperkalemia
- Addison's disease
- Hypersensitivity to Spironolactone, Furosemide, or sulphonamides
Side Effects
- Headache and drowsiness
- Gastrointestinal distress including cramp and diarrhea
- Ataxia, mental confusion, and skin rashes
- Gynaecomastia
- Endocrine disorders including hirsutism, deepening of voice, menstrual irregularities, and impotence
- Transient increase in blood-urea-nitrogen concentrations
- Mild acidosis
- Hyponatremia and hyperkalemia
- Excessive diuresis leading to dehydration and reduction in blood volume
- Serious depletion of potassium and magnesium leading to cardiac arrhythmias
Pregnancy & Lactation
- Spironolactone and its metabolites may cross the placental barrier
- Furosemide may cause fetal abnormalities
- Use of Furosemide only in women when appropriate contraceptive measures are taken or if benefits justify the potential risks to the fetus
- Metabolites of Spironolactone detected in breast milk
- Discontinue breastfeeding if Furosemide treatment is essential
Precautions & Warnings
- Caution in patients liable to electrolyte deficiency
- Use with caution in diabetes, enlarged prostate, hypotension, and hypovolemia
Therapeutic Class
- Potassium-sparing diuretics
- Aldosterone antagonists
Storage Conditions
- Keep below 30°C temperature
- Away from light and moisture
- Keep out of the reach of children