Furotone 20 mg+50 mg (Tablet)
Unit Price: ৳ 6.00 (30's pack: ৳ 180.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Furosemide spironolactone |
| Company | Novo healthcare and pharma ltd |
Indications
- Essential hypertension
- Chronic congestive heart failure
- Hepatic cirrhosis with collection of fluid in the abdominal cavity (ascites)
- Swelling due to excess fluid retention (edema)
- Hyperaldosteronism
- Resistant edema associated with secondary hyperaldosteronism
Pharmacology
- Complementary mechanisms of Spironolactone and Furosemide
- Additive or synergistic diuretic effect
- Inhibition of Na+/K+/2Cl- co-transporter by Furosemide
- Blockage of reabsorption of sodium, potassium, and chloride ions by Furosemide
- Antagonizing the action of aldosterone by Spironolactone
Dosage & Administration
- Dosage range of Furosemide 20 and Spironolactone 50 mg
- Flexible dosing based on patient's response
- Higher dosage for previously stabilized patients
- Not suitable for use in children
- Slower excretion in the elderly
Interaction
- Increased risk of hyperkalemia with ACE inhibitors or potassium salts
- Elevated levels of cardiac glycosides in the presence of Spironolactone
- Possible hypokalemia with corticosteroids and Spironolactone combination
- Potential reduction in diuretic effects when combined with indomethacin or NSAIDs
- Enhanced ototoxicity of aminoglycoside antibiotics with Furosemide
Contraindications
- Anuria
- Acute renal insufficiency
- Severe impairment of renal function
- Hyperkalemia
- Addison's disease
- Hypersensitivity to Spironolactone, Furosemide, or sulphonamides
Side Effects
- Headache and drowsiness
- Gastrointestinal distress
- Ataxia and mental confusion
- Gynaecomastia and breast enlargement
- Endocrine disorders including hirsutism and impotence
- Transient increase in blood-urea-nitrogen concentrations
- Hyponatremia and hyperkalemia
- Dehydration and reduction in blood volume
- Serious depletion of potassium and magnesium
Pregnancy & Lactation
- Crossing the placental barrier by Spironolactone and its metabolites
- Fetal abnormalities caused by Furosemide
- Consideration of benefits versus potential hazards in pregnant women
- Detection of metabolites in breast milk
- Discontinuation of breast-feeding if treatment is essential
Precautions & Warnings
- Caution in patients liable to electrolyte deficiency
- Use with caution in diabetes, enlarged prostate, hypotension, and hypovolemia
Therapeutic Class
- Potassium-sparing diuretics
- Aldosterone antagonists
Storage Conditions
- Keep below 30°C temperature
- Keep away from light and moisture
- Keep out of the reach of children