Zo-MUPS 20 mg (MUPS Tablet)

Unit Price: ৳ 11.00 (5 x 14: ৳ 770.00)
Strip Price: ৳ 154.00

Medicine Details

Category Details
Generic Esomeprazole mups preparation
Company Everest pharmaceuticals ltd
Also available as
Zo mups 40 mg tablet

Indications

  • Gastro-esophageal Reflux Disease (GERD)
  • Risk reduction in NSAID associated gastric ulcer
  • H. pylori eradication (Triple therapy)
  • Zollinger-Ellison syndrome and idiopathic hypersecretion

Composition

  • 20 mg Esomeprazole MUPS tablet contains 133.333 mg of Esomeprazole enteric coated pellets
  • 40 mg Esomeprazole MUPS tablet contains 266.67 mg of Esomeprazole enteric coated pellets

Description

  • Abbreviation: MUPS - Multiple-Unit Pellet System
  • Ensures greater bioavailability
  • Ensures uniform emptying of micro pellets from stomach into small intestine
  • Ensures lesser possibility of dose dumping
  • Combines fast acting and sustained action
  • Uniform drug release
  • Once daily dosing
  • Better than capsules in reducing the esophageal residence time
  • Minimizes fluctuation in plasma concentration of drug
  • Consistent and controlled pharmacological action

Pharmacology

  • Inhibits gastric acid by blocking the hydrogen-potassium adenosine triphosphatase enzyme system (proton pump) of the gastric parietal cell

Dosage

  • 40 mg once daily for adults with erosive esophagitis
  • 20 mg once daily for maintenance of healing of erosive esophagitis
  • 20 mg once daily for risk reduction in NSAID associated gastric ulcer for adults
  • 20 mg twice daily for H. pylori eradication in adults
  • 40-80 mg twice daily for Zollinger-Ellison syndrome and idiopathic hypersecretion in adults
  • 10-20 mg once daily for children 1-11 years with erosive esophagitis

Administration

  • Tablets should be swallowed whole with liquid, not chewed or crushed
  • Can be dispersed in water if needed, but not in carbonated water

Interaction

  • Not likely to inhibit certain CYP enzymes
  • May interfere with CYP2C19 and affect clearance of diazepam
  • Inhibits gastric acid secretion, potentially interfering with drug absorption where gastric pH is important

Contraindications

  • Contraindicated in patients with known hypersensitivity to any of the formulation

Side Effects

  • Headache
  • Diarrhoea
  • Nausea
  • Flatulence
  • Abdominal pain
  • Constipation
  • Dry mouth

Pregnancy & Lactation

  • Caution advised. Not known if Esomeprazole or its metabolites appear in human breast milk

Precautions & Warnings

  • Use with caution in patients with severe liver dysfunction and severe renal impairment
  • May slightly increase the risk of hip, wrist, and spine fracture over extended use

Storage Conditions

  • Store below 25°C, protect from light, keep out of reach of children

Compound Summary

  • Molecular Formula: C17H19N3O3S

Commonly Asked Questions

  • Proton pump inhibitor used for conditions involving excessive stomach acid
  • MUPS abbreviation for Multiple-Unit Pellet System
  • Relieves heartburn and aids in healing erosive esophagitis
  • Common side effects include headaches, diarrhea, nausea, and stomach pain
  • Caution advised during pregnancy or breastfeeding
  • Typically starts working within a few hours
  • Various quick tips for usage

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