Olanib 150 mg (Tablet)
Unit Price: ৳ 833.33 (1 x 120: ৳ 100,000.00)
Strip Price: ৳ 100,000.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Olaparib |
| Company | Everest pharmaceuticals ltd |
| Also available as |
Indications
- Breast Cancer
- Ovarian Cancer
Pharmacology
- PARP Enzyme Inhibition
- DNA Repair Inhibition
- Tumor Growth Inhibition
- Cell Cycle Regulation
Absorption
- Rapid Absorption
- Peak Plasma Concentration at 1-3 hours
- No Marked Accumulation
- Steady State Exposures
Distribution
- Apparent Volume of Distribution at Steady State
- In Vitro Protein Binding
Metabolism
- Primarily Metabolized by CYP3A4/5
- Oxidation Reactions
- Glucuronide or Sulfate Conjugation
Excretion
- Terminal Plasma Half-life
- Apparent Plasma Clearance
- Recovery of Dosed Radioactivity in Urine and Feces
Dosage & Administration
- Recommended Dosing of 400 mg Twice Daily
- Dose Modifications for Adverse Reactions
- Dose Modifications for Use with CYP3A Inhibitors
- Dosage Modifications for Patients with Renal Impairment
Interaction
- Potentiation and Prolongation of Myelosuppressive Toxicity
- Drugs That May Increase Plasma Concentrations
- Drugs That May Decrease Plasma Concentrations
Contraindications
- Hypersensitivity to Olaparib
Side Effects
- Common Serious Adverse Reactions
- Permanent Discontinuation Due to Adverse Events
Pregnancy & Lactation
- Fetal Harm
- Unknown Excretion in Human Milk
- Potential for Serious Adverse Reactions in Nursing Infants
Precautions & Warnings
- Incidence of Myelodysplastic Syndrome/Acute Myeloid Leukemia
- Pneumonitis
Overdose Effects
- No Specific Treatment Established
Therapeutic Class
- Targeted Cancer Therapy
Storage Conditions
- Store Below 30°C
- Protect from Light
- Keep Out of the Reach of Children