Lenvaxen 4 mg (Capsule)
Unit Price: ৳ 440.00 (1 x 30: ৳ 13,200.00)
Strip Price: ৳ 13,200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Lenvatinib mesylate |
| Company | Everest pharmaceuticals ltd |
| Also available as |
Title and Categories
- Lenvaxen - Kinase Inhibitor
- Pharmaceuticals
- Cancer Treatment
- Medical Supplies
Indications
- Differentiated Thyroid Cancer
- Renal Cell Carcinoma
- Hepatocellular Carcinoma
- Endometrial Carcinoma
Pharmacology
- Inhibition of VEGF receptors
- Inhibition of FGF receptors
- Antiproliferative activity in hepatocellular carcinoma cell lines
Absorption
- Time to peak plasma concentration
- Effect of high-fat meal on absorption
Distribution
- In vitro binding to human plasma proteins
- Blood-to-plasma concentration ratio
Metabolism
- Enzymatic (CYP3A and aldehyde oxidase) and non-enzymatic processes
Elimination
- Percentage eliminated in feces and urine
- Terminal elimination half-life
Dosage
- Dose reduction for renal or hepatic impairment
- Recommended dosages for different cancers
Administration
- Instructions for swallowing whole or dissolving in liquid
Interaction
- Avoid coadministration with drugs prolonging the QT interval
Contraindications
- Known hypersensitivity to Lenvatinib
Side Effects
- Hypertension
- Cardiac dysfunction
- Arterial thromboembolic events
- Hepatotoxicity
- Renal failure and impairment
- Diarrhea
- Fistula formation and gastrointestinal perforation
- QT Interval Prolongation
- Hypocalcemia
- Reversible posterior leukoencephalopathy syndrome
- Hemorrhagic events
- Impairment of thyroid stimulating hormone suppression/thyroid dysfunction
- Wound healing complications
Pregnancy & Lactation
- Potential embryo-fetal harm
- Use of effective contraception
- Discontinuation of breastfeeding
Precautions & Warnings
- Hypertension monitoring and control
- Monitoring for cardiac dysfunction
- Arterial Thromboembolic Events management
- Liver function monitoring
- Renal function monitoring
- Proteinuria monitoring
- Diarrhea management
- Fistula Formation and Gastrointestinal Perforation management
- Electrolyte abnormalities monitoring
- Thyroid function monitoring
- Wound Healing Complications management
Use in Special Populations
- Dosage modifications for severe renal impairment
- Dosage modifications for severe hepatic impairment
- Pediatric use information
Overdose Effects
- Expectation of non-dialyzable nature
- Recorded death due to multiorgan dysfunction from overdose
Storage Conditions
- Temperature and light requirements
- Safety measures for children