Ibruxen 140 mg (Capsule)
Unit Price: ৳ 1,320.00 (1 x 30: ৳ 39,600.00)
Strip Price: ৳ 39,600.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ibrutinib |
| Company | Everest pharmaceuticals ltd |
Indications
- Mantle Cell Lymphoma
- Chronic Lymphocytic Leukemia
- Waldenstrom Macroglobulinemia
- Marginal Zone Lymphoma
Pharmacology
Inhibitor of BTK; forms covalent bond with BTK active site; inhibits B-cell trafficking, chemotaxis, and adhesion
Dosage
- 560 mg for MCL and MZL
- 420 mg for CLL/SLL and WM
Administration
Orally once daily at approximately the same time each day; swallow capsules whole with water
Interaction
- Avoid co-administration with strong and moderate CYP3A inhibitors
- Avoid co-administration with strong CYP3A inducers
Contraindications
Hypersensitivity to the active substance or excipients
Side Effects
- Hemorrhage
- Infections
- Cytopenias
- Atrial Fibrillation
- Hypertension
- Diarrhea
- Visual Disturbance
Pregnancy & Lactation
- Can cause fetal harm
- Effects on breastfed infant unknown
Use in Special Populations
- Pediatric use not established
- Geriatric use observed in 62% patients ≥65 years
- Hepatic impairment safety not evaluated
Overdose Effects
No specific experience in management; closely monitor and provide appropriate supportive treatment
Therapeutic Class
Targeted Cancer Therapy
Storage Conditions
Store below 30°C, protect from light; keep out of reach of children