Elopag 25 mg (Tablet)
Unit Price: ৳ 500.00 (1 x 14: ৳ 7,000.00)
Strip Price: ৳ 7,000.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Eltrombopag olamine |
| Company | Everest pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of thrombocytopenia in patients with persistent or chronic immune thrombocytopenia
- Treatment of thrombocytopenia in patients with hepatitis C infection
- Treatment of severe aplastic anemia
Category
Medicine
Pharmacology
Eltrombopag Olamine is a small molecule thrombopoietin (TPO) receptor agonist. Eltrombopag interacts with the transmembrane domain of the human TPO-receptor and initiates signaling cascades that induce proliferation and differentiation from bone marrow progenitor cells finally leading to increased platelet production.
Dosage & Administration
- Route of Administration: Oral
- Recommendations:
- Take with or without a meal low in calcium
- Initiate at lowest effective dose for each indication
- Dose adjustments for different patient populations and conditions
Interaction
- Drug: Take eltrombopag at least 2 hours before or 4 hours after any medications or products containing polyvalent cations such as antacids and mineral supplements
- Food: Take eltrombopag at least 2 hours before or 4 hours after any calcium-rich foods
Contraindications
Known hypersensitivity to eltrombopag or any components of this product
Side Effects
- Anemia
- Nausea
- Pyrexia
- ALT increased
- Cough
- Fatigue
- Headache
- Diarrhea
Pregnancy & Lactation
Not recommended during pregnancy and lactation due to insufficient data
Precautions & Warnings
- Chronic Hepatitis C: May increase the risk of hepatic decompensation when combined with interferon and ribavirin
- Myelodysplastic Syndromes: Increased risk of death and progression to acute myeloid leukemia
- Portal Vein Thrombosis: Reported in patients with chronic liver disease receiving eltrombopag
Use in Special Populations
- Children and Adolescents: Safety and efficacy in pediatric patients below the age of 1 year with ITP have not been established
Overdose Effects
Platelet counts may increase excessively and result in thrombotic or thromboembolic complications
Therapeutic Class
Haemostatic drugs
Storage Conditions
Cool and dry place, protected from light, keep away from children