Sofoxen 400 mg (Tablet)

Unit Price: ৳ 600.00 (1 x 7: ৳ 4,200.00)
Strip Price: ৳ 4,200.00

Medicine Details

Category Details
Generic Sofosbuvir
Company Everest pharmaceuticals ltd

Indications

  • Treatment of chronic hepatitis C infection
  • Component of combination antiviral treatment regimen
  • Efficacy in subjects with HCV genotype 1, 2, 3 or 4 infection
  • Treatment of hepatocellular carcinoma meeting Milan criteria
  • Treatment of HCV/HIV-1 co-infection

Pharmacology

  • Nucleotide analog inhibitor
  • Specific inhibition of HCV NS5B RNA-dependent RNA polymerase
  • Prevents HCV viral replication
  • Acts as a chain terminator
  • Binds to Mg2+ ions present in HCV NS5B polymerase's GDD active site motif

Dosage & Administration

  • One 400 mg tablet taken once daily
  • Can be taken with or without food
  • Recommended combination therapies for different genotypes
  • Duration of treatment dependent on viral genotype and patient population
  • Use in combination with Ribavirin or Pegylated Interferon for treatment of CHC

Interaction

  • Reduced therapeutic effect with potent P-gp inducers
  • Potential interaction with modafinil and phenobarbital
  • Possible serious symptomatic bradycardia when co-administered with amiodarone

Contraindications

  • Contraindicated in pregnant women and men whose female partners are pregnant
  • Applicable contraindications for combination therapies with Ribavirin or Peginterferon alfa/Ribavirin

Side Effects

  • Common adverse events include fatigue, headache, nausea, insomnia, anemia

Pregnancy & Lactation

  • Pregnancy Category B
  • No adequate and well-controlled studies in pregnant women
  • Unknown presence in human breast milk

Precautions & Warnings

  • Risk of serious symptomatic bradycardia with amiodarone co-administration
  • Not recommended in combination with amiodarone and another direct acting antiviral
  • Cardiac monitoring recommended for patients without alternative viable treatment options

Use in Special Populations

  • Safety and effectiveness not established in children under 18 years of age
  • Response rates similar in subjects over 65 years of age
  • No dose adjustment warranted in geriatric patients

Overdose Effects

  • No specific antidote available
  • Treatment consists of general supportive measures and vital signs monitoring

Therapeutic Class

  • Hepatic viral infections (Hepatitis C)

Storage Conditions

  • Keep out of the reach of children
  • Store in a cool & dry place
  • Protect from light

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