Biotrim DS 800 mg+160 mg (Tablet)

Title

• Cotrimoxazole Double Strength Tablet

Categories

• Antibiotics
• Anti-infective Agents
• Sulphonamides & Trimethoprim

Description

• Bactericidal in vitro to a wide range of Gram-positive and Gram-negative organisms. Broad-spectrum bactericidal activity.
• Exerts its bactericidal action by the sequential blockade of two bacterial enzyme systems in the biosynthesis of Folinic acid.

Color Options

• White

Functions

• Treatment of respiratory tract infections
• Treatment of genito-urinary tract infections
• Treatment of gastro-intestinal tract infections
• Treatment of other infections where therapeutic benefits outweigh possible adverse events

Materials

• Sulphonamides
• Trimethoprim
• Folic acid

Technical Specifications

• Double Strength Tablet
• Trimethoprim and Sulphamethoxazole in a 1:5 combination

Design Elements

• Bactericidal action against a wide range of gram-positive and gram-negative bacteria
• Sequential blockade of bacterial enzyme systems

Usability Features

• Dosage suitable for different age groups
• Storage conditions: below 30°C, away from light & moisture, out of children's reach

Indications

• Respiratory tract infections
• Genito-urinary tract infections
• Gastro-intestinal tract infections
• Other confirmed susceptible infections

Pharmacology

• Broad spectrum bactericidal activity
• Acts against gram-positive & gram-negative bacteria and some protozoa

Dosage & Administration

• Different dosage for mild to severe infections
• Long term therapy dosage
• Dosage for gonorrhoea
• Dosage variation for different age groups

Contraindications

• Hypersensitivity to trimethoprim or sulphonamides
• Megaloblastic anaemia due to folate deficiency
• Liver parenchymal damage, blood dyscrasia, severe renal insufficiency, glucose 6-phosphate dehydrogenase deficiency

Side Effects

• Crystalluria
• Allergic reactions
• Haemolysis
• Thrombocytopenia
• Neutropenia
• Agranulocytosis
• Other less serious side effects such as malaise, headache, nausea, and vomiting

Pregnancy & Lactation

• Not recommended during pregnancy and nursing period

Precautions & Warnings

• Prolonged full dose treatment may risk macrocytic anaemia
• Care needed when giving to diabetic patients receiving sulphonylurea drug

Therapeutic Class

• Anti-diarrhoeal Antimicrobial drugs
• Sulphonamides & Trimethoprim

Storage Conditions

• Below 30°C temperature
• Away from light & moisture

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