Mepen 1 gm/vial (IV Injection or Infusion)

1 gm vial: ৳ 1,200.00

Medicine Details

Category Details
Generic Meropenem trihydrate
Company Biopharma limited
Also available as
Mepen 500 mg injection

Indications

  • Pneumonia and Nosocomial Pneumonia
  • Urinary Tract Infections
  • Intra-abdominal Infections
  • Gynaecological Infections
  • Skin and Skin Structure Infections
  • Meningitis
  • Septicaemia
  • Pulmonary infections in cystic fibrosis
  • Empiric treatment for presumed infections in patients with febrile neutropenia

Pharmacology

  • Bactericidal action
  • Interferes with bacterial cell wall synthesis
  • Potent against a broad spectrum of bacteria
  • Works against Gram-positive and Gram-negative bacteria
  • Aerobic and anaerobic bacterial activity

Dosage

  • Recommended daily dosage for adults and children
  • Intravenous administration
  • Dosage varies based on infection type and severity
  • Different dosages for different types of infections
  • No experience in children with hepatic or renal impairment

Administration

  • Administered by intravenous infusion over approximately 15-30 minutes
  • Can be given as intravenous bolus over approximately 3-5 minutes

Interaction

  • Interaction with Probenecid
  • Competes for active tubular secretion
  • Inhibition of renal excretion
  • Effect on plasma concentration of meropenem
  • Reduction of serum valproic acid levels

Contraindications

  • Contraindicated in patients with hypersensitivity

Side Effects

  • Inflammation
  • Thrombophlebitis
  • Pain at the site of injection
  • Skin reactions like rash, pruritus, urticaria
  • Abdominal pain
  • Nausea
  • Vomiting
  • Diarrhea
  • Headache

Pregnancy & Lactation

  • Pregnancy Category B
  • Use during pregnancy only if clearly needed
  • Caution during administration to nursing women

Precautions & Warnings

  • Discontinue in case of allergic reaction
  • Monitoring of transaminase and bilirubin levels in hepatic disease patients

Use in Special Populations

  • Dosage adjustments in renal impairment
  • No adjustments necessary in hepatic impairment
  • No dosage adjustments necessary in elderly unless creatinine clearance is <51 ml/min
  • Insufficient data for infants under 3 months

Overdose Effects

  • Accidental overdose risk in renal impairment patients
  • Symptomatic treatment for overdose

Therapeutic Class

  • Belongs to the Therapeutic Class of Other beta-lactam Antibiotics

Reconstitution

  • Preparation of intravenous bolus Administration
  • Preparation of intravenous infusion administration
  • Reconstitution with compatible infusion fluids

Storage Conditions

  • Vial storage below 30°C
  • Protection from light & moisture
  • Keep out of the reach of children

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