Napgin 500 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Naproxen sodium |
| Company | Biopharma limited |
Indications
- rheumatoid arthritis
- osteoarthritis
- ankylosing spondylitis
- juvenile arthritis
- tendonitis
- bursitis
- acute gout
- primary dysmenorrhea & pain
Pharmacology
Naproxen exerts its clinical effects by blocking COX-1 and COX-2 enzymes leading to decreased prostaglandin synthesis. COX-2 enzyme mediates the desired antipyretic, analgesic, and anti-inflammatory properties offered by Naproxen, while undesired adverse effects are linked to the COX-1 enzyme
Dosage & Administration
- Naproxen Enteric Coated Tablet: Adult: 500-1000 mg per day
- Naproxen Enteric Coated Tablet: Children: Not recommended
- Naproxen Suspension: Children over 2 years: 10 mg/kg/day
- Naproxen Gel: Applied 2-6 times a day
Interaction
- ACE inhibitors diminish the antihypertensive effect
- Antacids & Sucralfate delay absorption of Napgin
- Aspirin increases adverse effects
- Diuretics reduce natriuretic effect of Furosemide and Thiazides
- Methotrexate enhances the toxicity
- Warfarin increases the risk of GI bleeding
- Selective Serotonin Reuptake Inhibitors (SSRI) increase the risk of GI bleeding
Contraindications
Naproxen is contraindicated in patients with known hypersensitivity to Naproxen. It should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. It is contraindicated for the treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery
Side Effects
- Gastrointestinal: Heartburn, abdominal pain, nausea, diarrhea, dyspepsia
- Central Nervous System: Headache, vertigo, drowsiness
- Dermatological: Pruritus (itching), purpura
- Cardiovascular: Edema, palpitation
- Others: Visual disturbances, hearing disturbances
Pregnancy & Lactation
Naproxen may have adverse effects on the fetus. It causes a delay in parturition in animals and has been associated with premature closure of the ductus arteriosus and severe pulmonary hypertension in infants born to mothers taking Naproxen. The use of Naproxen in the first and third trimesters requires careful balancing of the benefits to the mother against the possible risks to the fetus. It is excreted in small amounts in the breast milk for nursing mothers
Precautions & Warnings
- Renal effects: Long-term administration of naproxen to animals has resulted in renal papillary necrosis and other abnormal renal pathology
- Hepatic effects: Reports of moderate to severe jaundice attributed to Naproxen
Therapeutic Class
- Drugs for Osteoarthritis
- Drugs used for Rheumatoid Arthritis
- Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Storage Conditions
Keep below 30°C temperature, protected from light & moisture, out of the reach of children