Depo-Medrol 80 mg/2 ml (Injection)
80 mg vial: ৳ 351.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Methylprednisolone acetate |
| Company | Pfizer |
| Also available as |
Title
- Methyl Prednisolone Acetate
Categories
- Medicine
- Pharmaceutical
Description
- Indicated for the treatment of asthma, atopic dermatitis, contact dermatitis, and other skin conditions
- Binds to and activates intracellular glucocorticoid receptors
- Dosage and administration instructions for local and systemic effect
- Potential side effects such as muscle weakness, osteoporosis, and convulsions
- Pregnancy category C - use in pregnancy, nursing mothers, or women of childbearing potential requires careful consideration
- Precautions for use in patients with ocular herpes simplex, renal insufficiency, hypertension, and myasthenia gravis
- Belongs to the therapeutic class of glucocorticoids
- Store between 20-25°C
Indications
- Treatment of asthma
- Treatment of atopic dermatitis
- Treatment of contact dermatitis
- Treatment of bullous dermatitis herpetiformis
- Treatment of mycosis fungoides
- Treatment of pemphigus
- Treatment of erythema multiforme
- Primary or secondary adrenocortical insufficiency
- Management of hypercalcemia associated with cancer
- Treatment of nonsuppurative thyroiditis
- Treatment of ulcerative colitis
- Treatment of hematologic disorders
- Palliative management of leukemias and lymphomas
- Treatment of sympathetic ophthalmia
- Treatment of keratitis
- Treatment of allergic conjunctivitis
- Treatment of juvenile rheumatoid arthritis
- Treatment of ankylosing spondylitis
- Management of symptomatic sarcoidosis
- Treatment of aspiration pneumonitis
Pharmacology
- Binds and activates intracellular glucocorticoid receptors
- Modifies transcription and protein synthesis
- Can inhibit leukocyte infiltration at the site of inflammation
- Interferes with mediators of inflammatory response
- Suppresses humoral immune responses
- Actions thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation
Dosage & Administration
- Administration for local effect - rheumatoid and osteoarthritis
- Administration for local effect - miscellaneous conditions (ganglion, tendinitis, epicondylitis)
- Administration for local effect - dermatological conditions
- Administration for systemic effect - adrenogenital syndrome
- Administration for systemic effect - maintenance of rheumatoid arthritis
- Administration for systemic effect - dermatologic lesions
- Administration for systemic effect - acute severe dermatitis due to poison ivy
- Administration for systemic effect - chronic contact dermatitis
- Administration for multiple sclerosis treatment
Interactions
- Convulsions reported with concurrent use of methylprednisolone and cyclosporine
- Drug interactions with hepatic enzyme inducers and inhibitors
- Reports of enhanced and diminished effects of anticoagulants when given concurrently with corticosteroids
Contraindications
- Contraindicated for intrathecal administration
- Contraindicated in systemic fungal infections
- Contraindicated in patients with known hypersensitivity to the product and its constituents
Side Effects
- Congestive heart failure
- Hypertension
- Sodium retention
- Muscle weakness
- Osteoporosis
- Peptic ulcer with possible subsequent hemorrhage
- Abdominal distension
- Increased sweating
- Convulsion
- Vertigo
- Headache
- Menstrual irregularities
- Secondary adrenocortical and pituitary unresponsiveness
- Increased intraocular pressure
- Glaucoma
- Allergic or hypersensitivity reactions
- Urticaria
- Hyperpigmentation or hypopigmentation
Pregnancy & Lactation
- Pregnancy Category C
- Use in pregnancy, nursing mothers, or women of childbearing potential requires careful consideration
Precautions & Warnings
- Use cautiously in patients with ocular herpes simplex
- Use cautiously in patients with nonspecific ulcerative colitis
- Use cautiously in patients with renal insufficiency
- Use cautiously in patients with hypertension
- Use cautiously in patients with osteoporosis
- Use cautiously in patients with myasthenia gravis
Therapeutic Class
- Glucocorticoids
Storage Conditions
- Store between 20-25°C